ArticlePloS one2013
Proximal arterial occlusion in acute ischemic stroke with low NIHSS scores should not be considered as mild stroke.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Intravenous alteplase in minor nondisabling ischemic stroke: A systematic review and meta-analysis.European stroke journal · 2024Pooled it
- Efficacy and safety of endovascular thrombectomy in mild ischemic stroke: results from a retrospective study and meta-analysis of previous trials.BMC neurology · 2019Pooled it
- Endovascular thrombectomy versus medical treatment for large vessel occlusion stroke with mild symptoms: A meta-analysis.PloS one · 2018Pooled it
- To do or not to do; dilemma of intra-arterial revascularization in acute ischemic stroke.PloS one · 2014Trial
- CT perfusion identified potential treatment opportunities in one in five mild strokes.Neurological research and practice · 2025Article
- Effectiveness and Limitations of Intravenous rt-PA Therapy in Patients with Mild Cerebral Infarction.Journal of atherosclerosis and thrombosis · 2025Review
- Mechanical thrombectomy for mild stroke with anterior circulation large vessel occlusion: a multicenter cohort study.Frontiers in neurology · 2025Article
- The value and limitations of the Oxford Community Stroke Project classification in the hyperacute phase of cerebral infarction.Frontiers in neurology · 2025Review
- The evolution of personalized stroke thrombectomy.Frontiers in surgery · 2025Review
- Quantitative insights into stroke recovery utilizing delayed vessel ratio from color-coded multiphase computed tomography angiography.Frontiers in neurology · 2025Article
- A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial.International journal of stroke : official journal of the International Stroke Society · 2024Article
- Endovascular Thrombectomy for Acute Ischemic Stroke : Current Concept in Management.Journal of Korean Neurosurgical Society · 2024Article
- Brain Frailty and Outcomes of Acute Minor Ischemic Stroke With Large-Vessel Occlusion.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Peripheral Lymphocyte-to-Monocyte Ratio as a Predictive Factor for Early Neurological Deterioration in Patients with Acute Ischemic Stroke.International journal of general medicine · 2024Article
- Outcome in acute ischemic stroke patients with large-vessel occlusion and initial mild deficits.Frontiers in stroke · 2024Article
- Intravenous thrombolysis versus antiplatelet therapy in minor stroke patients with large vessel occlusion.CNS neuroscience & therapeutics · 2023Article
- Decision-making strategies for reperfusion therapies: navigating through stroke trials gaps.Arquivos de neuro-psiquiatria · 2022Article
- Perfusion profile evaluated by severity-weighted multiple Tmax strata predicts early neurological deterioration in minor stroke with large vessel occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Observational
- Factors associated with functional disability in patients with acute stroke excluded from alteplase administration due to minor non-disabling neurological deficits.Frontiers in neurology · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUntreated acute mild stroke patients have substantial 90-day disability rates and worse outcomes than those who are treated with thrombolysis. There is little information regarding which patients with acute mild stroke will benefit from thrombolysis. We sought to investigate factors that are associated with early neurological deterioration (END) and poor prognosis in patients with acute mild stroke.
methodsThis was a retrospective study of consecutively registered patients with acute mild stroke (NIHSS ≤3) at our tertiary stroke center between October 2008 and December 2011. END was defined as an increase in NIHSS ≥2 points between hospital days 0 and 5. Modified Rankin Scale (mRS) scores of 0-1 at 90 days post-stroke were defined as favorable outcomes.
resultsA total of 378 (mean age, 65.9±13.0 years) patients were included in this study. END occurred in 55 patients (14.6%). IV-thrombolysis was performed in only 9 patients. Symptomatic arterial occlusion on the initial MRA was independently associated with END (OR, 2.206; 95% CI, 1.219-3.994; p = 0.009) by multivariate logistic regression. Of the 119 patients with symptomatic arterial occlusion, ICA occlusion was independently associated with END (OR, 8.606; 95% CI, 2.312-32.043; p = 0.001).
conclusionsThis study demonstrates that symptomatic arterial occlusion may be an important predictor of END in patients with acute mild stroke. It may therefore be important to consider that acute ischemic stroke with symptomatic arterial occlusion and low NIHSS scores may not represent mild stroke in acute periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.