ArticleAdvanced functional materials2012
Ellipsoidal Polyaspartamide Polymersomes with Enhanced Cell-Targeting Ability.
Article in Advanced functional materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions.Journal of functional biomaterials · 2025Review
- Polymersome-based protein drug delivery - quo vadis?Chemical Society reviews · 2023Review
- Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery.Nanomaterials (Basel, Switzerland) · 2022Review
- Combining Nanoparticle Shape Modulation and Polymersome Technology in Drug Delivery.ACS applied bio materials · 2021Review
- Polymerization-Induced Polymersome Fusion.Journal of the American Chemical Society · 2019Article
- Faceted polymersomes: a sphere-to-polyhedron shape transformation.Chemical science · 2019Article
- Design of an Amphiphilic Poly(aspartamide)-mediated Self-assembled Nanoconstruct for Long-Term Tumor Targeting and Bioimaging.Molecules (Basel, Switzerland) · 2019Article
- Engineering Polymersomes for Diagnostics and Therapy.Advanced healthcare materials · 2018Review
- Article
- Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity.ACS applied materials & interfaces · 2017Article
- Emergence and Utility of Nonspherical Particles in Biomedicine.Industrial & engineering chemistry research · 2015Article
- Non-Spherical Particles for Targeted Drug Delivery.Chemical engineering science · 2015Article
- Polymersome-based drug-delivery strategies for cancer therapeutics.Therapeutic delivery · 2015Review
- Tailoring polymersome bilayer permeability improves enhanced permeability and retention effect for bioimaging.ACS applied materials & interfaces · 2014Article
- Flow-mediated stem cell labeling with superparamagnetic iron oxide nanoparticle clusters.ACS applied materials & interfaces · 2013Article
- Leukocyte-mimicking stem cell delivery via in situ coating of cells with a bioactive hyperbranched polyglycerol.Journal of the American Chemical Society · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Nano-sized polymersomes functionalized with peptides or proteins are being increasingly studied for targeted delivery of diagnostic and therapeutic molecules. Earlier computational studies have suggested that ellipsoidal nanoparticles, compared to spherical ones, display enhanced binding efficiency with target cells, but this has not yet been experimentally validated. We hypothesize that hydrophilic polymer chains coupled to vesicle-forming polymers would result in ellipsoidal polymersomes. In addition, ellipsoidal polymersomes modified with cell adhesion peptides bind with target cells more actively than spherical ones. We examine this hypothesis by substituting polyaspartamide with octadecyl chains and varying numbers of poly(ethylene glycol) (PEG) chains. Increasing the degree of substitution of PEG from 0.5 to 1.0 mol% drives the polymer to self-assemble into an ellipsoidal polymersome with an aspect ratio of 2.1. Further modification of these ellipsoidal polymersomes with peptides containing an Arg-Gly-Asp sequence (RGD peptides) lead to a significant increase in the rate of association and decrease in the rate of dissociation with a substrate coated with α
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