ArticleJournal of proteomics & bioinformatics2013
Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma.
Article in Journal of proteomics & bioinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- Towards Precision Dermatology: Emerging Role of Proteomic Analysis of the Skin.Dermatology (Basel, Switzerland) · 2022Review
- Integrated Quantitative Phosphoproteomics and Cell-based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-related Phosphorylation Sites.Molecules and cells · 2021Article
- Investigating Serum and Tissue Expression Identified a Cytokine/Chemokine Signature as a Highly Effective Melanoma Marker.Cancers · 2020Article
- Proteomic Profiling of Archived Tissue of Primary Melanoma Identifies Proteins Associated with Metastasis.International journal of molecular sciences · 2020Article
- Proteomic measures of gamma oscillations.Heliyon · 2019Article
- Melanoma proteomics suggests functional differences related to mutational status.Scientific reports · 2019Article
- Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data.Scientific reports · 2019Article
- Targeting L-Lactate Metabolism to Overcome Resistance to Immune Therapy of Melanoma and Other Tumor Entities.Journal of oncology · 2019Review
- Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.Journal of proteome research · 2018Article
- Indicators of responsiveness to immune checkpoint inhibitors.Scientific reports · 2017Article
- Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.American journal of physiology. Renal physiology · 2017Article
- Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1.Clinical proteomics · 2017Article
- Correlation of histopathologic characteristics to protein expression and function in malignant melanoma.PloS one · 2017Article
- Mass spectrometry-assisted gel-based proteomics in cancer biomarker discovery: approaches and application.Theranostics · 2017Review
- Article
- Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome.Oncology letters · 2016Article
- Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.Aging cell · 2016Article
- Proteomics and melanoma: a current perspective.Global dermatology · 2016Article
- Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Proteomic Findings in Melanoma.Journal of proteomics & bioinformatics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Molecular pathways regulating melanoma initiation and progression are potential targets of therapeutic development for this aggressive cancer. Identification and molecular analysis of these pathways in patients has been primarily restricted to targeted studies on individual proteins. Here, we report the most comprehensive analysis of formalin-fixed paraffin-embedded human melanoma tissues using quantitative proteomics. From 61 patient samples, we identified 171 proteins varying in abundance among benign nevi, primary melanoma, and metastatic melanoma. Seventy-three percent of these proteins were validated by immunohistochemistry staining of malignant melanoma tissues from the Human Protein Atlas database. Our results reveal that molecular pathways involved with tumor cell proliferation, motility, and apoptosis are mis-regulated in melanoma. These data provide the most comprehensive proteome resource on patient melanoma and reveal insight into the molecular mechanisms driving melanoma progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.