ArticleJournal of molecular neuroscience : MN2013
Immunohistochemical localization of α2-adrenergic receptors in the neonatal rat cochlea and the vestibular labyrinth.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 12 citations in OpenAlex.
- Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation.Molecular neurobiology · 2024Review
- Expression and localization of αEuropean journal of histochemistry : EJH · 2023Article
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- Neurobiology of Stress-Induced Tinnitus.Current topics in behavioral neurosciences · 2021Article
- βScientific reports · 2017Article
- Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin.Audiology & neuro-otology · 2017Article
- A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere's disease.Human molecular genetics · 2016Article
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6 authors at 3 institutions in 1 country.
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Abstract
The α2-adrenergic receptors (α2-ARs), which mediate physiological responses to noradrenaline and adrenaline, are encoded by three different genes but all are coupled to the Gi/Go subfamily of G proteins. The present study investigated the localization of three subtypes, i.e., α2a-, α2b-, and α2c-ARs, in cochlea and vestibular labyrinth in rat in the early postnatal period by immunohistochemistry. The results showed that α2-ARs were widely distributed in regions, including the organ of Corti, spiral ganglion neurons, stria vascularis, crista ampullaris, Scarpa's ganglion, utricle, and Reissner's membrane. Furthermore, the cellular locations of α2-ARs between different cell subtypes as well as receptor subtypes and different observed time points also had diversity. α2a-AR mainly targeted to nuclei at postnatal ages (P)3. While at P(8), only ganglion neurons maintained this character whereas other cell types expressed α2a-AR mainly in plasma membrane. The α2b- and α2c-ARs exhibited predominantly in plasma membrane. Compared with P(8), α2c-AR was not present at stria vascularis at P(3). Overall, our observations indicated that there was region-specific regulation of α2-ARs development in cochlea and vestibular labyrinth. In addition, the extensive expressions of α2-ARs established a significant foundation for the exploration of the function of α2-ARs in cochlea and vestibular labyrinth.
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