ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Epidemic increase in Salmonella bloodstream infection in children, Bwamanda, the Democratic Republic of Congo.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 7 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.The Lancet. Infectious diseases · 2022Pooled it
- A Systematic Review of Typhoid Fever Occurrence in Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- Antimicrobial resistance among children in sub-Saharan Africa.The Lancet. Infectious diseases · 2018Pooled it
- Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Antimicrobial resistance in Africa: a systematic review.BMC infectious diseases · 2017Pooled it
- An Appraisal of the Clinical Features of Pediatric Enteric Fever: Systematic Review and Meta-analysis of the Age-Stratified Disease Occurrence.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Pooled it
- A Systematic Review of the Incidence, Risk Factors and Case Fatality Rates of Invasive Nontyphoidal Salmonella (iNTS) Disease in Africa (1966 to 2014).PLoS neglected tropical diseases · 2017Pooled it
- Antimicrobial resistance in Enterobacterales infections among children in sub-Saharan Africa: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- The Prevalence of Malaria and Bacteremia Co-Infections among Febrile Patients: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2022Review
- The Burden of Typhoid Fever in Sub-Saharan Africa: A Perspective.Research and reports in tropical medicine · 2022Review
- Direct association between rainfall and non-typhoidal Salmonella bloodstream infections in hospital-admitted children in the Democratic Republic of Congo.Scientific reports · 2021Article
- High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya.PLoS neglected tropical diseases · 2020Article
- Non-typhoidal Salmonella bloodstream infections in Kisantu, DR Congo: Emergence of O5-negative Salmonella Typhimurium and extensive drug resistance.PLoS neglected tropical diseases · 2020Article
- Increased growth rate and amikacin resistance of Salmonella enteritidis after one-month spaceflight on China's Shenzhou-11 spacecraft.MicrobiologyOpen · 2019Article
- Salmonella Typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Occurrence, Genetic Diversities And Antibiotic Resistance Profiles OfInfection and drug resistance · 2019Article
- Diagnostic Bacteriology in District Hospitals in Sub-Saharan Africa: At the Forefront of the Containment of Antimicrobial Resistance.Frontiers in medicine · 2019Review
- Trends in paediatric and adult bloodstream infections at a Ghanaian referral hospital: a retrospective study.Annals of clinical microbiology and antimicrobials · 2016Article
- Microbiological, clinical and molecular findings of non-typhoidal Salmonella bloodstream infections associated with malaria, Oriental Province, Democratic Republic of the Congo.BMC infectious diseases · 2016Article
- Towards Improving Point-of-Care Diagnosis of Non-malaria Febrile Illness: A Metabolomics Approach.PLoS neglected tropical diseases · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica is the leading cause of bloodstream infection in children in sub-Saharan Africa, but few data are available from Central-Africa. We documented during the period November 2011 to May 2012 an epidemic increase in invasive Salmonella bloodstream infections in HGR Bwamanda, a referral hospital in Equateur Province, DR Congo. Salmonella spp. represented 90.4 % (103 out of 114) of clinically significant blood culture isolates and comprised Salmonella Typhimurium (54.4 %, 56 out of 103), Salmonella Enteritidis (28.2 %, 29 out of 103) and Salmonella Typhi (17.5 %, 18 out of 103), with Salmonella Enteritidis accounting for most of the increase. Most (82 out of 103, 79.6 %) isolates were obtained from children < 5 years old. Median ages of patients infected with Salmonella Typhimurium and Salmonella Enteritidis were 14 months (14 days to 64 years) and 19 months (3 months to 8 years) respectively. Clinical presentation was non-specific; the in-hospital case fatality rate was 11.1 %. More than two thirds (69.7 %, 53 out of 76) of children < 5 years for whom laboratory data were available had Plasmodium falciparum infection. Most (83/85, 97.6 %) non-typhoid Salmonella isolates as well as 6/18 (33.3 %) Salmonella Typhi isolates were multidrug resistant (i.e. resistant to the first-line oral antibiotics amoxicillin, trimethoprim-sulfamethoxazole and chloramphenicol), one (1.0 %) Salmonella Typhimurium had decreased ciprofloxacin susceptibility owing to a point mutation in the gyrA gene (Gly81Cys). Multilocus variable-number tandem-repeat (MLVA) analysis of the Salmonella Enteritidis isolates revealed closely related patterns comprising three major and four minor profiles, with differences limited to one out of five loci. These data show an epidemic increase in clonally related multidrug-resistant Salmonella bloodstream infection in children in DR Congo.
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