Trial reportAIDS and behavior2013
Does effective depression treatment alone reduce secondary HIV transmission risk? Equivocal findings from a randomized controlled trial.
Trial report in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review.Frontiers in public health · 2026Pooled it
- Pooled it
- Syndemics of psychosocial problems and HIV risk: A systematic review of empirical tests of the disease interaction concept.Social science & medicine (1982) · 2015Pooled it
- Reliability and validity of depression assessment among persons with HIV in sub-Saharan Africa: systematic review and meta-analysis.Journal of acquired immune deficiency syndromes (1999) · 2014Pooled it
- Does substance use compromise depression treatment in persons with HIV? Findings from a randomized controlled trial.AIDS care · 2017Trial
- Trial
- Changes in sexual behavior of HIV-infected older adults enrolled in a clinical trial of standalone group psychotherapies targeting depression.AIDS and behavior · 2015Trial
- The Increased Risk for HIV and Other Sexually Transmitted Infections Among Substance-Using and Depressed Women in the Legal System.Journal of healthcare, science and the humanities · 2021Article
- Association between internalized stigma and depression among HIV-positive persons entering into care in Southern India.Journal of global health · 2017Article
- Associations between Mental Health and Ebola-Related Health Behaviors: A Regionally Representative Cross-sectional Survey in Post-conflict Sierra Leone.PLoS medicine · 2016Article
- Psychological symptoms are associated with both abstinence and risky sex among men with HIV.Archives of sexual behavior · 2015Article
- Cognitive impairment in patients with AIDS - prevalence and severity.HIV/AIDS (Auckland, N.Z.) · 2015Review
- Declining prevalence of probable depression among patients presenting for antiretroviral therapy in rural Uganda: the role of early treatment initiation.AIDS and behavior · 2015Article
- Is the glass half full or half empty? Treatment of depression and HIV/AIDS medication adherence: a comment on Sin and DiMatteo.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
Abstract
Depressed mood has been associated with HIV transmission risk behavior. To determine whether effective depression treatment could reduce the frequency of sexual risk behavior, we analyzed secondary outcome data from a 36-week, two-arm, parallel-design, randomized controlled trial, in which homeless and marginally housed, HIV-infected persons with comorbid depressive disorders were randomized to receive either: (a) directly observed treatment with the antidepressant medication fluoxetine, or (b) referral to a local public mental health clinic. Self-reported sexual risk outcomes, which were measured at 3, 6, and 9 months, included: total number of sexual partners, unprotected sexual intercourse, unprotected sexual intercourse with an HIV-uninfected partner or a partner of unknown serostatus, and transactional sex. Estimates from generalized estimating equations regression models did not suggest consistent reductions in sexual risk behaviors resulting from treatment. Mental health interventions may need to combine depression treatment with specific skills training in order to achieve durable impacts on HIV prevention outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.