ArticleClinical oral investigations2014
Fluoride releasing and enamel demineralization around orthodontic brackets by fluoride-releasing composite containing nanoparticles.
Article in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Influence of resin-modified glass ionomer and topical fluoride on levels of Streptococcus mutans in saliva and biofilm adjacent to metallic brackets.Journal of applied oral science : revista FOBTrial
- Association Between Cross-Sectional Geometry and Cyclic Fatigue Resistance of Nickel-Titanium Endodontic Instruments: A Systematic Review.Journal of functional biomaterials · 2026Review
- Effect of yttrium/lanthanum-doped ultrasonically assisted nano-hydroxyapatite on remineralization and bracket bond strength in artificial enamel lesions.BMC oral health · 2025Article
- Evaluation of Factors Influencing Fluoride Release from Dental Nanocomposite Materials: A Systematic Review.Nanomaterials (Basel, Switzerland) · 2025Review
- Brazilian red propolis as a potential antimicrobial additive in orthodontic primers.Brazilian dental journal · 2025Article
- The Efficacy of Photodynamic Therapy againstActa medica Philippina · 2025Article
- White Spot Lesions in Fixed Orthodontics: A Literature Review on Etiology, Prevention, and Treatment.Cureus · 2024Review
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- Article
- Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth.Gels (Basel, Switzerland) · 2023Review
- Randomized in situ evaluation of surface polishing protocols on the caries-protective effect of resin Infiltrant.Scientific reports · 2022Article
- Application of Nanotechnology in Orthodontic Materials: A State-of-the-Art Review.Dentistry journal · 2020Review
- Effect of high-fluoride dentifrice and bracket bonding composite material on enamel demineralization in situ.Clinical oral investigations · 2020Article
- Functional Coatings for Orthodontic Archwires-A Review.Materials (Basel, Switzerland) · 2020Review
- Comparison of intraoral biofilm reduction on silver-coated and silver ion-implanted stainless steel bracket material : Biofilm reduction on silver ion-implanted bracket material.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2019Article
- Human In Situ Study of the effect of Bis(2-Methacryloyloxyethyl) Dimethylammonium Bromide Immobilized in Dental Composite on Controlling Mature Cariogenic Biofilm.International journal of molecular sciences · 2018Article
- Effect of CO2 Laser and Fluoride Varnish Application on Microhardness of Enamel Surface Around Orthodontic Brackets.Journal of lasers in medical sciences · 2018Article
- Antimicrobial and physical characteristics of orthodontic primers containing antimicrobial agents.The Angle orthodontist · 2017Article
- Glass hybrid, but not calcium hydroxide, remineralized artificial residual caries lesions in vitro.Clinical oral investigations · 2017Article
- Efficacy of four preventive measures against enamel demineralization at the bracket periphery-comparison of microhardness and confocal laser microscopy analysis.Clinical oral investigations · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFluoride-containing materials have been suggested to control enamel demineralization around orthodontic brackets during the treatment with fixed appliances. The improvement of their properties has been made through innovations, such as the application of nanotechnology by incorporation of nanofillers.
objectiveThis in vitro study evaluated the capacity of fluoride releasing and enamel demineralization inhibition of fluoride-releasing nanofilled cement around orthodontic brackets using an artificial caries biofilm model. MATERIALS AND
methodsForty bovine enamel discs were selected by evaluating surface microhardness and randomized into four groups (n = 10): non-fluoride-releasing microfilled composite, fluoride-releasing microfilled composite, resin-modified glass ionomer cement (RMGI), and fluoride-releasing nanofilled composite (FN). After brackets bonding in each disc, the specimens were subjected to a cariogenic challenge through a Streptococcus mutans biofilm model. After the experimental period, the biofilm formed around the brackets was collected for fluoride analysis and the mineral loss around the brackets was determined by integrated demineralization via cross-sectional microhardness measurement at 20 and 70 μm from the bracket margin. Additionally, samples of each group were subjected to energy-dispersive X-ray spectroscopy (EDX) analysis examined under a scanning electron microscopy (SEM). ANOVA followed by Tukey test were applied for fluoride concentration and mineral loss data, respectively.
resultsAt both distances, only RMGI statistically differed from the other groups presenting the lowest demineralization, although there was a trend to a lower demineralization of enamel around brackets in FN group. Similar condition was found to fluoride concentration and EDX/SEM analysis.
conclusionsUnder the cariogenic exposure condition of this study, the fluoride-releasing nanofilled material had similar performance to fluoride-releasing microfilled materials. CLINICAL RELEVANCE: The presence of nanofillers in the fluoride-releasing materials studied did not promote further benefits against caries lesion development around brackets and presented inferior demineralization inhibition than the resin-modified glass ionomer material.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.