ArticleNucleus (Austin, Tex.)
Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.EMBO reports · 2026Article
- A distinct isoform of Msp300 (nesprin) organizes the perinuclear microtubule-organizing center in adipocytes.Molecular biology of the cell · 2025Article
- Lamin A upregulation reorganizes the genome during rod photoreceptor degeneration.Cell death & disease · 2023Article
- Nuclear envelope transmembrane proteins involved in genome organization are misregulated in myotonic dystrophy type 1 muscle.Frontiers in cell and developmental biology · 2022Article
- Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Casz1 controls higher-order nuclear organization in rod photoreceptors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The KASH-containing isoform of Nesprin1 giant associates with ciliary rootlets of ependymal cells.Neurobiology of disease · 2018Article
- Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning.Current biology : CB · 2017Article
- Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.Current biology : CB · 2017Article
- Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation.Molecular neurobiology · 2017Article
- Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development.Molecular biology of the cell · 2016Article
- Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner.Journal of visualized experiments : JoVE · 2015Article
- A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I.Neurobiology of disease · 2015Article
- A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.Investigative ophthalmology & visual science · 2015Article
- Nuclear envelope: positioning nuclei and organizing synapses.Current opinion in cell biology · 2015Review
- Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Development (Cambridge, England) · 2015Article
- Nuclear envelope and genome interactions in cell fate.Frontiers in genetics · 2015Review
- Temporal and tissue-specific disruption of LINC complexes in vivo.Genesis (New York, N.Y. : 2000) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sun proteins and Nesprins are two families of proteins whose direct interactions across the nuclear envelope provide for the core of Linkers of the Nucleoskeleton to the Cytoskeleton (LINC complexes) that physically connect the nucleus interior to cytoskeletal networks. Whereas LINC complexes play essential roles in nuclear migration anchorage and underlie normal CNS development, the developmental regulation of their composition remains largely unknown. In this study, we examined the spatiotemporal expression of lamins, Sun proteins and Nesprins during postnatal mouse retinal development. Whereas retinal precursor cells mostly express B-type lamins, Sun1, and high molecular weight isoforms of Nesprins, post-mitotic retinal cells are characterized by a drastic downregulation of the latter, the expression of A-type lamins, and the strong induction of a specific isoform of Nesprin1 late in retinal development. Importantly, our results emphasize different spatiotemporal expression for Nesprin1 and Nesprin2 and further suggest an important role for KASH-less isoforms of Nesprin1 in the CNS. In conclusion, the transition from retinal precursor cells undergoing interkinetic nuclear migration to post-mitotic retinal cells undergoing nuclear translocation and/or anchorage is accompanied by a profound remodeling of LINC complexes composition. This remodeling may reflect different requirements of nuclear dynamics at different stages of CNS development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.