ArticleNeurochemical research2013
Store-operated Ca2+ channels blockers inhibit lipopolysaccharide induced astrocyte activation.
Article in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Store-operated calcium entry drives alcohol-exacerbated neuroinflammation in retinal degeneration.Cell death discovery · 2026Article
- NMDARs antagonist MK801 suppresses LPS-induced apoptosis and mitochondrial dysfunction by regulating subunits of NMDARs via the CaM/CaMKII/ERK pathway.Cell death discovery · 2023Article
- Massive efflux of adenosine triphosphate into the extracellular space immediately after experimental traumatic brain injury.Experimental and therapeutic medicine · 2021Article
- CaNaunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Calcium release-activated calcium channels and pain.Cell calcium · 2018Review
- Reactive Astrocytes in Glioblastoma Multiforme.Molecular neurobiology · 2018Review
- Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells.Frontiers in pharmacology · 2017Article
- The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia.Journal of neuroinflammation · 2016Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The destruction of calcium homeostasis is an important factor leading to neurological diseases. Store-operated Ca(2+) (SOC) channels are essential for Ca(2+) homeostasis in many cell types. However, whether SOC channels are involved in astrocyte activation induced by lipopolysaccharide (LPS) still remains unknown. In this study, we used LPS as an exogenous stimulation to investigate the role of SOC channels in astrocyte activation. Using calcium imaging technology, we first found that SOC channels blockers, 1-[h-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole (SKF-96365) and 2-aminoethyldiphenyl borate (2-APB), inhibited LPS induced [Ca(2+)]i increase, which prompted us to speculate that SOC channels may be involved in LPS induced astrocyte activation. Further experiments confirmed our speculation shown as SOC channels blockers inhibited LPS induced astrocyte activation characterized as cell proliferation by MTS and BrdU assay, raise in glial fibrillary acidic protein expression by immunofluorescence and Western Blot and secretion of interleukin 6 (IL-6) and interleukin 1β (IL-1β) by ELISA. So, our studies showed that SOC channels are involved in LPS-induced astrocyte activation.
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Registered trials
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