SynthesisJournal of neuro-oncology2013
Neurocognitive deficits following primary brain tumor treatment: systematic review of a decade of comparative studies.
Synthesis in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review.Journal of neuro-oncology · 2023Pooled it
- Working memory training for adult glioma patients: a proof-of-concept study.Journal of neuro-oncology · 2021Trial
- Development of an EORTC questionnaire measuring instrumental activities of daily living (IADL) in patients with brain tumours: phase I-III.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Trial
- Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial.Journal of neuro-oncology · 2019Trial
- Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro-QoL Cognition Function Scale.Cancer medicine · 2026Observational
- Brain state theory as a comprehensive model for addressing the "non-eloquent" brain in glioma surgery.Journal of neuro-oncology · 2025Article
- Development of a brief screening measure of unmet supportive care needs (SCNS-P&C-6) in caregivers of people with high-grade glioma.Journal of patient-reported outcomes · 2025Article
- Long-term neurocognitive and psychological outcomes in meningioma survivors: Individual changes over time and radiation dosimetry.Neuro-oncology practice · 2024Article
- Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors.Journal of neuro-oncology · 2023Article
- Surveillance of long-term complications after treatment of adult brain tumor survivors-review and evidence-based recommendations.Neuro-oncology practice · 2022Review
- Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration.Metabolites · 2022Review
- Characterization of Cognitive Function in Survivors of Diffuse Gliomas Using Morphometric Correlation Networks.Tomography (Ann Arbor, Mich.) · 2022Article
- Characterization of cognitive function in survivors of diffuse gliomas using resting-state functional MRI (rs-fMRI).Brain imaging and behavior · 2022Article
- Patient-reported functional executive challenges and caregiver confirmation in adult brain tumor survivors.Journal of cancer survivorship : research and practice · 2021Article
- Adolescent and young adult neuro-oncology: a comprehensive review.Neuro-oncology practice · 2021Review
- Late Sequelae of Radiotherapy—The Effect of Technical and Conceptual Innovations in Radiation Oncology.Deutsches Arzteblatt international · 2021Review
- Insulin signaling mediates neurodegeneration in glioma.Life science alliance · 2021Article
- Computerized Symbol Digit Modalities Test in a Swiss Pediatric Cohort Part 1: Validation.Frontiers in psychology · 2021Article
- Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration.PLoS biology · 2019Article
- Subjective cognitive functioning and associations with psychological distress in adult brain tumour survivors.Journal of cancer survivorship : research and practice · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been an increase in the prevalence of adults diagnosed with and treated for primary brain tumors. Cognitive deficits are a common long-term effect in brain tumor survivors. The objective of this paper is to examine whether these deficits are specific to those diagnosed with and treated for a primary brain tumor. A systematic review of the medical literature from 2002 to 2012 was conducted to investigate neurocognitive deficits in brain tumor survivors (post-primary treatment) compared to healthy controls. Four studies were identified that met all inclusion criteria. Gliomas were the most common form of tumor included. Neuropsychological evaluation identified cognitive deficits in brain tumor survivors on tests of working memory, cognitive control and flexibility, cognitive processing speed, visual searching, planning and foresight, and general attention. While age, education, and gender can influence cognitive function, the present review indicates that deficits exist beyond those accounted for by these factors. Many primary brain tumor survivors are involved in roles (e.g., employee, parent, spouse/partner, student) that require optimal performance of these cognitive skills. Future research should evaluate brain tumor survivors on functional challenges resulting from these cognitive sequelae and develop effective ways to mitigate them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.