ArticleImmunogenetics2013
Killer cell immunoglobulin-like receptor (KIR) genes and their HLA-C ligands in a Ugandan population.
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- High KIR diversity in Uganda and Botswana children living with HIV.Human immunology · 2026Article
- Global patterns of KIR genotype diversity reflect human migration and regional differences.Frontiers in immunology · 2026Article
- Review
- Unveiling the Significance of HLA and KIR Diversity in Underrepresented Populations.Biomedicines · 2024Review
- High-resolution KIR and HLA genotyping in three Chinese ethnic minorities reveals distinct origins.HLA · 2024Article
- Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population.Innate immunity · 2023Article
- TheFrontiers in immunology · 2023Article
- Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.The Journal of infectious diseases · 2021Article
- Association of killer cell immunoglobulin-like receptors with endemic Burkitt lymphoma in Kenyan children.Scientific reports · 2021Article
- Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.Malaria journal · 2021Article
- High-Resolution Analysis Identifies High Frequency ofFrontiers in immunology · 2021Article
- The Genetic Mechanisms Driving Diversification of theFrontiers in immunology · 2020Review
- Haplotype-Based Analysis ofFrontiers in immunology · 2020Article
- qKAT: Quantitative Semi-automated Typing of Killer-cell Immunoglobulin-like Receptor Genes.Journal of visualized experiments : JoVE · 2019Article
- Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.Human immunology · 2018Article
- The direct and sustained consequences of severe placental hypoxia on vascular contractility.PloS one · 2018Article
- KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.Immunity, inflammation and disease · 2017Article
- Pregnancy disorders in Africa and the obstetric dilemma.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2016Article
- qKAT: a high-throughput qPCR method for KIR gene copy number and haplotype determination.Genome medicine · 2016Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Killer cell immunoglobulin-like receptor (KIR) genes are expressed by natural killer cells and encoded by a family of genes exhibiting considerable haplotypic and allelic variation. HLA-C molecules, the dominant ligands for KIR, are present in all individuals and are discriminated by two KIR epitopes, C1 and C2. We studied the frequencies of KIR genes and HLA-C1 and C2 groups in a large cohort (n = 492) from Kampala, Uganda, East Africa and compared our findings with published data from other populations in sub-Saharan Africa (SSA) and several European populations. We find considerably more KIR diversity and weaker linkage disequilibrium in SSA compared to the European populations and describe several novel KIR genotypes. C1 and C2 frequencies were similar to other SSA populations with a higher frequency of the C2 epitope (54.9 %) compared to Europe (average 39.7 %). Analysis of this large cohort from Uganda in the context of other African populations reveals variations in KIR and HLA-C1 and C2 that are consistent with migrations within Africa and potential selection pressures on these genes. Our results will help understand how KIR/HLA-C interactions contribute to resistance to pathogens and reproductive success.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.