ArticlePhysical biology2013
Platelet size and density affect shear-induced thrombus formation in tortuous arterioles.
Article in Physical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Natural and long-term preservable anticoagulant property of SiOFrontiers in bioengineering and biotechnology · 2025Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- Quantifying Platelet Margination in Diabetic Blood Flow.Biophysical journal · 2018Article
- Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.Biosensors · 2018Review
- Method for the simulation of blood platelet shape and its evolution during activation.PLoS computational biology · 2018Article
- Age-related Impairment of Vascular Structure and Functions.Aging and disease · 2017Review
- Numerical Simulation of Thrombotic Occlusion in Tortuous Arterioles.Journal of cardiology and cardiovascular medicine · 2017Article
- The role of platelet count, mean platelet volume, and the mean platelet volume/platelet count ratio in predicting postoperative vomiting in children after deep sedation.Saudi medical journal · 2016Article
- Article
- Metabolomic Analysis of Biochemical Changes in the Plasma of High-Fat Diet and Streptozotocin-Induced Diabetic Rats after Treatment with Isoflavones Extract of Radix Puerariae.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes.European journal of inflammation · 2015Article
- Simulation of the microscopic process during initiation of stent thrombosis.Computers in biology and medicine · 2015Article
- Mean platelet volume as a negative marker of inflammation in children with rotavirus gastroenteritis.Iranian journal of pediatrics · 2014Article
- Effect of Red Blood Cells on Platelet Activation and Thrombus Formation in Tortuous Arterioles.Frontiers in bioengineering and biotechnology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Thrombosis accounts for 80% of deaths in patients with diabetes mellitus. Diabetic patients demonstrate tortuous microvessels and larger than normal platelets. Large platelets are associated with increased platelet activation and thrombosis, but the physical effects of large platelets in the microscale processes of thrombus formation are not clear. Therefore, the objective of this study was to determine the physical effects of mean platelet volume (MPV), mean platelet density (MPD) and vessel tortuosity on platelet activation and thrombus formation in tortuous arterioles. A computational model of the transport, shear-induced activation, collision, adhesion and aggregation of individual platelets was used to simulate platelet interactions and thrombus formation in tortuous arterioles. Our results showed that an increase in MPV resulted in a larger number of activated platelets, though MPD and level of tortuosity made little difference on platelet activation. Platelets with normal MPD yielded the lowest amount of mural thrombus. With platelets of normal MPD, the amount of mural thrombus decreased with increasing level of tortuosity but did not have a simple monotonic relationship with MPV. The physical mechanisms associated with MPV, MPD and arteriole tortuosity play important roles in platelet activation and thrombus formation.
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