ArticleThe Journal of biological chemistry2013
RecA protein recruits structural maintenance of chromosomes (SMC)-like RecN protein to DNA double-strand breaks.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Species-specific coevolution of RecA-RecN interfaces governs DNA double-strand break repair in Escherichia coli.PLoS genetics · 2026Article
- RecN and RecA orchestrate an ordered DNA supercompaction response following ciprofloxacin-induced DNA damage in Escherichia coli.Nucleic acids research · 2025Article
- Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization.Nucleic acids research · 2024Article
- The SMC-like RecN protein is at the crossroads of several genotoxic stress responses inFrontiers in microbiology · 2023Article
- Beneficial and detrimental genes in the cellular response to replication arrest.PLoS genetics · 2022Article
- Phage Genes Induce Quorum Sensing Signal Release through Membrane Vesicle Formation.Microbes and environments · 2022Article
- A novel structural maintenance of chromosomes (SMC)-related protein family specific to Archaea.Frontiers in microbiology · 2022Article
- RecA Is Required for the Assembly of RecN into DNA Repair Complexes on the Nucleoid.Journal of bacteriology · 2021Article
- A combination of Class-I fumarases and metabolites (α-ketoglutarate and fumarate) signal the DNA damage response inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- An Epistasis Analysis ofGenetics · 2020Article
- The Interaction of RecA With Both CheA and CheW Is Required for Chemotaxis.Frontiers in microbiology · 2020Article
- Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic.Nature communications · 2019Article
- Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes.Molecular microbiology · 2019Article
- Topological DNA-binding of structural maintenance of chromosomes-like RecN promotes DNA double-strand break repair inCommunications biology · 2019Article
- Limited Capacity or Involvement of Excision Repair, Double-Strand Breaks, or Translesion Synthesis for Psoralen Cross-Link Repair inGenetics · 2018Article
- Survival of Helicobacter pylori in gastric acidic territory.Helicobacter · 2017Review
- The cohesin-like RecN protein stimulates RecA-mediated recombinational repair of DNA double-strand breaks.Nature communications · 2017Article
- Management of E. coli sister chromatid cohesion in response to genotoxic stress.Nature communications · 2017Article
- ComB proteins expression levels determine Helicobacter pylori competence capacity.Scientific reports · 2017Article
- In vitro topological loading of bacterial condensin MukB on DNA, preferentially single-stranded DNA rather than double-stranded DNA.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli RecN is an SMC (structural maintenance of chromosomes) family protein that is required for DNA double-strand break (DSB) repair. Previous studies show that GFP-RecN forms nucleoid-associated foci in response to DNA damage, but the mechanism by which RecN is recruited to the nucleoid is unknown. Here, we show that the assembly of GFP-RecN foci on the nucleoid in response to DNA damage involves a functional interaction between RecN and RecA. A novel RecA allele identified in this work, recA(Q300R), is proficient in SOS induction and repair of UV-induced DNA damage, but is deficient in repair of mitomycin C (MMC)-induced DNA damage. Cells carrying recA(Q300R) fail to recruit RecN to DSBs and accumulate fragmented chromosomes after exposure to MMC. The ATPase-deficient RecN(K35A) binds and forms foci at MMC-induced DSBs, but is not released from the MMC-induced DNA lesions, resulting in a defect in homologous recombination-dependent DSB repair. These data suggest that RecN plays a crucial role in homologous recombination-dependent DSB repair and that it is required upstream of RecA-mediated strand exchange.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.