A new signaling paradigm to control the prenylation and trafficking of small GTPases.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B.International journal of molecular sciences · 2021
   Article
2. SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families.Frontiers in molecular biosciences · 2021
   Review
3. Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.Cells · 2020
   Review
4. The Hypervariable Region of K-Ras4B Governs Molecular Recognition and Function.International journal of molecular sciences · 2019
   Review
5. Structural Insights into the Regulation Mechanism of Small GTPases by GEFs.Molecules (Basel, Switzerland) · 2019
   Review
6. The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases.The Journal of biological chemistry · 2019
   Article
7. GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2018
   Article
8. RHO GTPases in cancer: known facts, open questions, and therapeutic challenges.Biochemical Society transactions · 2018
   Review
9. Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.The Journal of biological chemistry · 2017
   Article
10. Arg188 drives RhoC membrane binding.Small GTPases · 2017
    Article

Corrections and comments

• Comment on
  An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.2013

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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