ReviewGastroenterology2013
The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry.
Review in Gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04798547 (Outcomes of Short-length vs Standard-length Myotomy Using Per-Oral Endoscopic Myotomy), which is not on this map. Cited by 98 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of Short-length vs Standard-length Myotomy Using Per-Oral Endoscopic Myotomy (POEM) for Achalasia: A Randomized Controlled Pilot Study
Who cites it
98 citing papers in PubMed, 4 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- Long-term outcomes after per-oral endoscopic myotomy versus laparoscopic Heller myotomy in the treatment of achalasia: a systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- Esophageal and Oropharyngeal Dysphagia: Clinical Recommendations From the United European Gastroenterology and European Society for Neurogastroenterology and Motility.United European gastroenterology journal · 2025Guideline
- Clinical characteristics and manometric findings of esophageal achalasia-a systematic review regarding differences among three subtypes.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2023Pooled it
- Clinical Practice Update: The Use of Per-Oral Endoscopic Myotomy in Achalasia: Expert Review and Best Practice Advice From the AGA Institute.Gastroenterology · 2017Guideline
- Efficacy and safety of acotiamide in esophagogastric junction outflow obstruction: a placebo-controlled phase II trial.Esophagus : official journal of the Japan Esophageal Society · 2026Trial
- Laparoscopic Heller myotomy or pneumatic dilatation in achalasia: results of a prospective, randomized study with at least a decade of follow-up.Surgical endoscopy · 2021Trial
- Treatment of achalasia with laparoscopic myotomy or pneumatic dilatation: long-term results of a prospective, randomized study.World journal of surgery · 2015Trial
- Esophageal peristalsis in health and disease: mechanistic insights.Physiological reviews · 2026Review
- Modern treatment for achalasia: endoscopic and surgical therapies.The British journal of surgery · 2026Review
- Hormone replacement therapy and the risk of achalasia in postmenopausal women: A nationwide cohort study.Medicine · 2026Article
- MULTICHANNEL INTRALUMINAL IMPEDANCE MAY BE USEFUL TO IDENTIFY CLINICALLY RELEVANT ESOPHAGOGASTRIC JUNCTION OUTFLOW OBSTRUCTION.Arquivos de gastroenterologia · 2026Article
- What worsens swallowing in esophageal achalasia? Insights from patient-reported outcomes.Frontiers in nutrition · 2026Article
- Fibrosis in the Hiatus of Esophagus in Patients With Primary Esophageal Motor Disorders: Radiomic Analysis.Neurogastroenterology and motility · 2025Article
- The Impact of the Oral and Esophageal Microbiota in EoE and Achalasia.Journal of clinical medicine · 2025Review
- Additional Diagnostic Yield of Ambulatory 24-h High Resolution Manometry With Impedance in Patients With Non-Cardiac Chest Pain or Non-Obstructive Dysphagia.Neurogastroenterology and motility · 2025Article
- Obesity Impacts the Likelihood of Symptom Resolution in Patients with Esophagogastric Junction Outflow Obstruction.Dysphagia · 2025Article
- Is Roux-en-Y gastrojejunostomy an adequate anti-reflux operation after esophagogastric myotomy?Surgical endoscopy · 2025Article
- The Reverse Red-Green-Blue Rule: A Color-Coded Approach for Simplified Achalasia Diagnosis via High-Resolution Manometry.Gastroenterology research · 2025Article
- Optimizing achalasia diagnosis in the era of high-resolution manometry: A Pakistani perspective.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Clinical and high-resolution manometry of 801 patients with esophageal dysmotility, including achalasia, in relation to age.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
High-resolution manometry and recently described analysis algorithms, summarized in the Chicago Classification, have increased the recognition of achalasia. It has become apparent that the cardinal feature of achalasia, impaired lower esophageal sphincter relaxation, can occur in several disease phenotypes: without peristalsis, with premature (spastic) distal esophageal contractions, with panesophageal pressurization, or with peristalsis. Any of these phenotypes could indicate achalasia; however, without a disease-specific biomarker, no manometric pattern is absolutely specific. Laboratory studies indicate that achalasia is an autoimmune disease in which esophageal myenteric neurons are attacked in a cell-mediated and antibody-mediated immune response against an uncertain antigen. This autoimmune response could be related to infection of genetically predisposed subjects with herpes simplex virus 1, although there is substantial heterogeneity among patients. At one end of the spectrum is complete aganglionosis in patients with end-stage or fulminant disease. At the opposite extreme is type III (spastic) achalasia, which has no demonstrated neuronal loss but only impaired inhibitory postganglionic neuron function; it is often associated with accentuated contractility and could be mediated by cytokine-induced alterations in gene expression. Distinct from these extremes is progressive plexopathy, which likely arises from achalasia with preserved peristalsis and then develops into type II achalasia and then type I achalasia. Variations in its extent and rate of progression are likely related to the intensity of the cytotoxic T-cell assault on the myenteric plexus. Moving forward, we need to integrate the knowledge we have gained into treatment paradigms that are specific for individual phenotypes of achalasia and away from the one-size-fits-all approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.