ArticleNeurobiology of learning and memory2013
Egr-1 increases in the prefrontal cortex following training in the context preexposure facilitation effect (CPFE) paradigm.
Article in Neurobiology of learning and memory, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Fear extinction is impaired in aged rats.GeroScience · 2024Article
- Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions.Frontiers in behavioral neuroscience · 2024Article
- Functional network of contextual and temporal memory has increased amygdala centrality and connectivity with the retrosplenial cortex, thalamus, and hippocampus.Scientific reports · 2023Article
- Unique roles for the anterior and posterior retrosplenial cortices in encoding and retrieval of memory for context.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference.Frontiers in behavioral neuroscience · 2022Article
- Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory.Neurobiology of learning and memory · 2021Article
- Molecularly Defined Hippocampal Inputs Regulate Population Dynamics in the Prelimbic Cortex to Suppress Context Fear Memory Retrieval.Biological psychiatry · 2020Article
- Article
- Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats.Neurobiology of learning and memory · 2019Article
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Contextual fear retrieval-induced Fos expression across early development in the rat: An analysis using established nervous system nomenclature ontology.Neurobiology of learning and memory · 2018Article
- Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.Developmental neurobiology · 2017Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Novelty and fear conditioning induced gene expression in high and low states of anxiety.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Article
- Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.Neural plasticity · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The context pre-exposure facilitation effect (CPFE) is a modified form of standard contextual fear conditioning that dissociates learning about the context during a preexposure phase from learning the context-shock association during an immediate shock training phase conducted on separate days. Fear conditioning in the CPFE is an associative process in which only animals that are preexposed to the same context they are later given an immediate shock in demonstrate freezing when tested for conditioned fear memory. Previous research has shown that the hippocampus and amygdala are necessary for different phases of the CPFE, but whether other brain regions are also involved is unknown. The present study examined expression of the immediate-early gene early growth response gene 1 (Egr-1; also called Zif268, Ngfi-a, Krox-24) in the dorsal hippocampus, lateral nucleus of the amygdala, retrosplenial cortex, and several prefrontal cortex regions (infralimbic and prelimbic medial prefrontal cortex, anterior cingulate, and orbitofrontal cortex) following each phase of the CPFE in juvenile rats. Animals preexposed to the conditioning context displayed fear conditioned freezing during a retention test whereas rats preexposed to an alternate context did not. Following context preexposure, Egr-1 mRNA was elevated in context and alternate context exposed animals compared to home-cage control rats in almost all regions analyzed. Following the context-shock training phase, fear conditioned rats displayed significantly more Egr-1 mRNA expression in the infralimbic, prelimbic, and orbitofrontal cortices compared to the alternate context preexposed control rats. These differences in Egr-1 expression were not found in amygdala between the preexposed context and alternate context rats. No sex differences were observed following preexposure or training in any regions analyzed. The findings suggest that increased expression of Egr-1 within the prefrontal cortex is associated with contextual fear conditioning in the CPFE paradigm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.