Evidence map›Paper›PMID 23973342›Full record

ReviewVaccine2013

A maternal vaccine against group B Streptococcus: past, present, and future.

Vincent L Chen, Fikri Y Avci, Dennis L Kasper

Open access · greenAbstract readReview
In one paragraph

Review in Vaccine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 89 citations in OpenAlex.

  1. Bacterial and fungal infections in infants born before 24 weeks' gestation: a review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Updates on Group BMicroorganisms · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Future vaccines in pregnancy.Best practice & research. Clinical obstetrics & gynaecology · 2021
    Review
  13. Article
  14. Phylogeny, recombination, and invasiveness of group B Streptococcus revealed by genomic comparisons of its global strains.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  15. Review
  16. Streptococcus agalactiae in pregnant women: serotype and antimicrobial susceptibility patterns over five years in Eastern Sicily (Italy).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  17. [Relationship of group BZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020
    Article
  18. Prevalence and capsular type distribution of group BIranian journal of microbiology · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Vincent L ChenDivision of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. vincent_chen2@hms.harvard.edu
Fikri Y Avci
Dennis L Kasper
Brigham and Women's Hospital · USHarvard University · US

Funding

Knowledge-based Vaccines Built on Paradigm Changes in Antigen PresentationR01AI089915 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2011 to 2015
$2.1M
NIAID NIH HHS R01 AI089915
6 · The paper itself

Abstract

Group B Streptococcus (GBS) is a major cause of morbidity and mortality among neonates. Though there have been tremendous advances in prevention of invasive neonatal GBS disease through prophylactic antibiotic treatment of pregnant women, the incidence of neonatal disease has not changed significantly over the past several years. Vaccination of pregnant women is an important strategy that has the potential to improve further on existing protocols. In this review, we explore the history of the design of maternal GBS vaccines. We also discuss how recent applications of genomics and immunology to vaccine design promise to further enhance our ability to develop more effective vaccines against this important disease.

Indexed as

Antibodies, BacterialFemaleHumansInfant, NewbornInfant, Newborn, DiseasesPolysaccharides, BacterialPregnancyReproductive Tract InfectionsStreptococcal InfectionsStreptococcal VaccinesStreptococcus agalactiaeVaccinationAntibodies, BacterialPolysaccharides, BacterialStreptococcal Vaccinescapsular polysaccharideCapsular polysaccharideCPSGBSGlycoconjugategroup B StreptococcusGroup B StreptococcusIgimmunoglobulinmajor histocompatibility complexMaternalMechanismMHCOVAovalbuminReverse vaccinologytetanus toxoidTT

Identifiers

PMID23973342
PMCPMC3757342
OpenAlexW2029768750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.