ArticleOsteoarthritis and cartilage2013
The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy.
Article in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Intra-articular Delivery of Recombinant Interleukin-1 Receptor Antagonist Protein (Anakinra) Enhances Graft Function in a Porcine Model of Osteochondral Repair.The American journal of sports medicine · 2026Article
- A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis.Osteoarthritis and cartilage · 2024Article
- Preoperative Synovial Tissue and Synovial Fluid Biomarkers as Predictors for Outcomes After Knee Arthroscopy and ACL Reconstruction: A Narrative Review.Orthopaedic journal of sports medicine · 2024Review
- Modulating mechanobiology as a therapeutic target for synovial fibrosis to restore joint lubrication.Osteoarthritis and cartilage · 2024Article
- The Corticosteroid Meniscectomy Trial of Extended-Release Triamcinolone Injection After Arthroscopic Partial Meniscectomy: Protocol for a Double-Blind Randomized Controlled Trial.Orthopaedic journal of sports medicine · 2023Article
- Macroscopic Synovial Inflammation Correlates with Symptoms and Cartilage Lesions in Patients Undergoing Arthroscopic Partial Meniscectomy: A Clinical Study.Journal of clinical medicine · 2022Article
- Do Synovial Inflammation and Meniscal Degeneration Impact Clinical Outcomes of Patients Undergoing Arthroscopic Partial Meniscectomy? A Histological Study.International journal of molecular sciences · 2022Article
- Six-Month Outcomes of Clinically Relevant Meniscal Injury in a Large-Animal Model.Orthopaedic journal of sports medicine · 2021Review
- Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.Frontiers in cell and developmental biology · 2021Review
- Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement.Journal of orthopaedic surgery and research · 2020Observational
- Substantive molecular and histological changes within the meniscus with tears.BMC musculoskeletal disorders · 2019Article
- 1,25-Dihydroxyvitamin D3 attenuates disease severity and induces synoviocyte apoptosis in a concentration-dependent manner in rats with adjuvant-induced arthritis by inactivating the NF-κB signaling pathway.Journal of bone and mineral metabolism · 2019Article
- Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy.Journal of experimental orthopaedics · 2017Article
- Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears.Osteoarthritis and cartilage · 2015Article
- Emerging targets in osteoarthritis therapy.Current opinion in pharmacology · 2015Review
- From repair to regeneration: biomaterials to reprogram the meniscus wound microenvironment.Annals of biomedical engineering · 2015Review
- Osteoarthritis pain: nociceptive or neuropathic?Nature reviews. Rheumatology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveSynovitis is associated with pain and other symptoms in patients with knee osteoarthritis (OA), and in patients with meniscal tears even in the absence of radiographic OA. Patients undergoing arthroscopic partial meniscectomy were followed for 2 years to determine whether synovitis predicts post-operative symptoms.
designThirty-three patients scheduled for arthroscopy were recruited for this pilot study. Symptoms were assessed using a knee pain scale, the Lysholm score, and the short form-12 (SF-12(®)) pre-operatively and at 16 weeks, 1 year and 2 years post-operatively. Synovial inflammation and hyperplasia were graded on surgical biopsies. Linear mixed effects models were tested to determine whether inflammation or hyperplasia is associated with outcome scores over time.
resultsLysholm scores and SF-12(®) physical component sub-scores were worse pre-operatively in patients with inflammation (Lysholm: 52.42 [95% confidence interval (CI) 42.37, 62.47] vs 72.38 [66.03, 78.72], P < 0.001; SF-12: 36.81 [28.26, 45.37] vs 46.23 [40.14, 52.32], P < 0.05). Up to 2-years post-operatively, patients with inflammation achieved mean scores similar to those without inflammation. As a result, the mean improvement in Lysholm scores was 13.01 [1.48-24.53] points higher than patients without inflammation, P = 0.03. 33% (4/12) of patients with inflammation still had fair to poor Lysholm scores 2 years after surgery compared to 7% (1/15, P=0.14) without inflammation. No association between hyperplasia and symptoms was noted.
conclusionsIn this pilot study of patients undergoing partial meniscectomy, synovial inflammation was associated with worse pre-operative symptoms, but not with poorer outcomes in the first 2 years post-arthroscopy. Larger cohorts and longer follow-up should be pursued to confirm this relationship, and determine if the initial response is sustained.
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