Trial reportOsteoarthritis and cartilage2013
Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis--treatment effects of neuromuscular exercise and total joint replacement.
Trial report in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05167877 (Studying Aging, Mobility and Chronic Low Back Pain in Older Adults Using Remote Monitoring), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studying Aging, Mobility and Chronic Low Back Pain in Older Adults Using Remote Monitoring
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Pain's Adverse Impact on Training-Induced Performance and Neuroplasticity: A Systematic Review.Brain imaging and behavior · 2022Pooled it
- Efficacy of proprioceptive training on the recovery of total joint arthroplasty patients: a meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?International journal of rheumatic diseases · 2026Trial
- Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis.Arthritis research & therapy · 2018Trial
- Feasibility and Preliminary Effects of Adding Percutaneous Electrical Nerve Stimulation to a Pain Education and Exercise Program in Patients with Knee Osteoarthritis: A Pilot Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Pre-Exercise Factors Associated with the Magnitude of Exercise-Induced Hypoalgesia in Individuals with Knee Osteoarthritis: A Cross-Sectional, Observational Study.Journal of clinical medicine · 2025Article
- From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?Annals of the rheumatic diseases · 2024Review
- Exercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial.BMJ open · 2024Article
- A scoping review of prehabilitation interventions for arthroplasty patients.The South African journal of physiotherapy · 2023Article
- A probiotic intervention on pain hypersensitivity and microbiota composition in patients with osteoarthritis pain: Study protocol for a randomized controlled trial.Archives of rheumatology · 2021Article
- Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis: a substudy within the Physical Activity in Rheumatoid Arthritis 2010 study.Arthritis research & therapy · 2018Article
- Similar patient-reported outcomes and performance after total knee arthroplasty with or without patellar resurfacing.Acta orthopaedica · 2016Article
- Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain.Current osteoporosis reports · 2015Review
- Three weeks of exercise therapy altered brain functional connectivity in fibromyalgia inpatients.Neurobiology of pain (Cambridge, Mass.)Article
- The autonomic and nociceptive response to acute exercise is impaired in people with knee osteoarthritis.Neurobiology of pain (Cambridge, Mass.)Article
- The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia.Neurobiology of pain (Cambridge, Mass.)Article
- Review
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess exercise induced analgesia (EIA) and pain sensitivity in hip and knee osteoarthritis (OA) and to study the effects of neuromuscular exercise and surgery on these parameters.
designThe dataset consisted of knee (n = 66) and hip (n = 47) OA patients assigned for total joint replacement at Lund University Hospital undergoing pre-operative neuromuscular exercise and 43 matched controls. Sensitivity to pressure pain was assessed by pressure algometry at 10 sites. Subjects were then instructed to perform a standardized static knee extension. Pressure pain thresholds (PPTs) were assessed at the contracting quadriceps muscle (Q) and at the resting deltoid muscle (D) before and during contraction. The relative increase in PPTs during contraction was taken as a measure of localized (Q) or generalized (D) EIA. Patients were assessed at baseline, following on average 12 weeks of neuromuscular exercise and 3 months following surgery.
resultsWe found a normal function of EIA in OA patients at baseline. Previous studies have reported beneficial effects of physical exercise on pain modulation in healthy subjects. However, no treatment effects on EIA were seen in OA patients despite the increase in muscle strength following neuromuscular exercise and reduced pain following surgery. Compared to controls, OA patients had increased pain sensitivity and no beneficial effects on pain sensitivity were seen following treatment.
conclusionsTo our knowledge, this is the first study of EIA in OA patients. Despite increased pain sensitivity, OA patients had a normal function of EIA.
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