ArticleOsteoarthritis and cartilage2013
Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis.
Article in Osteoarthritis and cartilage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Effects of transcranial direct current stimulation on pain and physical function in patients with knee osteoarthritis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2024Pooled it
- Racial-Ethnic Differences in Osteoarthritis Pain and Disability: A Meta-Analysis.The journal of pain · 2019Pooled it
- Impact of Therapeutic Interventions on Pain Intensity and Endogenous Pain Modulation in Knee Osteoarthritis: A Systematic Review and Meta-analysis.Pain medicine (Malden, Mass.) · 2019Pooled it
- Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature.BMC musculoskeletal disorders · 2016Pooled it
- High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression.CartilagePooled it
- Effects of Non-Immersive Virtual Reality Exercise on Self-Reported Pain and Mechanical Hyperalgesia in Older Adults with Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- Functional Near-Infrared Spectroscopy to Assess Central Pain Responses in a Nonpharmacologic Treatment Trial of Osteoarthritis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Trial
- Feasibility and efficacy of remotely supervised cranial electrical stimulation for pain in older adults with knee osteoarthritis: A randomized controlled pilot study.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Trial
- Trial
- Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: Protocol for a Prospective Cohort Study.JMIR research protocols · 2026Article
- Ipsilateral Knee Pain After Total Hip Arthroplasty: Pathogenesis and Intervention Strategies-A Narrative Review.Journal of pain research · 2026Review
- Experimental Pain Phenotypes in Individuals With Symptomatic Knee Osteoarthritis: A Neural Network-Based Clustering Approach.Pain research & management · 2026Article
- Influence of Pain, Risk Factors, and Functional Ability on Physical Activity Levels in Women with Anterior Knee Pain: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Pre-operative pain pressure threshold association with patient satisfaction following Total Knee Arthroplasty.Journal of orthopaedics · 2024Article
- Mechanical hyperalgesia and neuropathic pain qualities impart risk for chronic postoperative pain after total knee replacement.medRxiv : the preprint server for health sciences · 2024Article
- Association of mechanical temporal summation of pain with muscle co-contraction during walking in people with knee osteoarthritis.Clinical biomechanics (Bristol, Avon) · 2023Article
- Efficiency of pain inhibition and facilitation of fibromyalgia patients is not different from healthy controls: Relevance of sensitivity-adjusted test stimuli.British journal of pain · 2023Article
- Associations between pain catastrophizing and resting-state functional brain connectivity: Ethnic/race group differences in persons with chronic knee pain.Journal of neuroscience research · 2022Observational
- The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?International journal of molecular sciences · 2022Review
- Patterns and Correlates of Self-Management Strategies for Osteoarthritis-Related Pain Among Older Non-Hispanic Black and Non-Hispanic White Adults.Arthritis care & research · 2021Observational
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
objectivePain in knee osteoarthritis (OA) has historically been attributed to peripheral pathophysiology; however, the poor correspondence between objective measures of disease severity and clinical symptoms suggests that non-local factors, such as altered central processing of painful stimuli, also contribute to clinical pain in knee OA. Consistent with this notion, recent evidence demonstrates that patients with knee OA exhibit increased sensitivity to painful stimuli at body sites unaffected by clinical pain.
designIn order to further investigate the contribution of altered pain processing to knee OA pain, the current study tested the hypothesis that symptomatic knee OA is associated with enhanced sensitivity to experimental pain stimuli at the knee and at remote body sites unaffected by clinical pain. We further anticipated that pain sensitivity would differ as a function of the OA symptom severity. Older adults with and without symptomatic knee OA completed a series of experimental pain assessments. A median split of the Western Ontario and McMaster Universities Index of Osteoarthritis (WOMAC) was used to stratify participants into low vs high OA symptom severity.
resultsCompared to controls and the low symptom group, individuals in the high symptom group were more sensitive to suprathreshold heat stimuli, blunt pressure, punctuate mechanical, and cold stimuli. Individuals in the low symptomatic OA group subgroup exhibited experimental pain responses similar to the pain-free group on most measures. No group differences in endogenous pain inhibition emerged.
conclusionsThese findings suggest that altered central processing of pain is particularly characteristic of individuals with moderate to severe symptomatic knee OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.