ArticleBiophysical journal2013
Detection of cochlear amplification and its activation.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Including two-dimensional pressure-focusing in transmission-line cochlear models.JASA express letters · 2026Article
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- Active deformation in the basal organ of Corti in gerbil.Biophysical journal · 2026Article
- An alternative pathway for delivery of power by outer hair cells to cochlear traveling waves.Hearing research · 2026Article
- Low-side and multitone suppression in the base of the gerbil cochlea.Biophysical journal · 2025Article
- Outer hair cells stir cochlear fluids.eLife · 2025Article
- Article
- Outer hair cells stir cochlear fluids.bioRxiv : the preprint server for biology · 2024Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements.Biophysical journal · 2024Article
- Regional differences in cochlear nonlinearity across the basal organ of Corti of gerbil: Regional differences in cochlear nonlinearity.Hearing research · 2024Article
- Advective mass transport along the cochlear coil.AIP conference proceedings · 2024Article
- Fluid Focusing Contributes to the BM Vibration Amplification by Boosting the Pressure.AIP conference proceedings · 2024Article
- Imaging the Ear Anatomy and Function Using Optical Coherence Tomography Vibrometry.Seminars in hearing · 2024Review
- Optogenetics Reveals Roles for Supporting Cells in Force Transmission to and From Outer Hair Cells in the Mouse Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex.The Journal of the Acoustical Society of America · 2023Article
- A chemo-mechanical cochleostomy preserves hearing for the in vivo functional imaging of cochlear cells.Nature protocols · 2023Review
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Broad nonlinearity in reticular lamina vibrations requires compliant organ of Corti structures.Biophysical journal · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
26 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
The operation of the mammalian cochlea relies on a mechanical traveling wave that is actively boosted by electromechanical forces in sensory outer hair cells (OHCs). This active cochlear amplifier produces the impressive sensitivity and frequency resolution of mammalian hearing. The cochlear amplifier has inspired scientists since its discovery in the 1970s, and is still not well understood. To explore cochlear electromechanics at the sensory cell/tissue interface, sound-evoked intracochlear pressure and extracellular voltage were measured using a recently developed dual-sensor with a microelectrode attached to a micro-pressure sensor. The resulting coincident in vivo observations of OHC electrical activity, pressure at the basilar membrane and basilar membrane displacement gave direct evidence for power amplification in the cochlea. Moreover, the results showed a phase shift of voltage relative to mechanical responses at frequencies slightly below the peak, near the onset of amplification. Based on the voltage-force relationship of isolated OHCs, the shift would give rise to effective OHC pumping forces within the traveling wave peak. Thus, the shift activates the cochlear amplifier, serving to localize and thus sharpen the frequency region of amplification. These results are the most concrete evidence for cochlear power amplification to date and support OHC somatic forces as its source.
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