ArticleBiophysical journal2013
A mechanistic model of Ca regulation of thin filaments in cardiac muscle.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Generative adversarial networks for construction of virtual populations of mechanistic models: simulations to study Omecamtiv Mecarbil action.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Functional outcomes of structural peculiarities of striated muscle tropomyosin.Journal of muscle research and cell motility · 2020Review
- A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics.Biophysical journal · 2019Article
- Tropomyosin dynamics during cardiac muscle contraction as governed by a multi-well energy landscape.Progress in biophysics and molecular biology · 2019Article
- Effects of an Interchain Disulfide Bond on Tropomyosin Structure: A Molecular Dynamics Study.International journal of molecular sciences · 2018Article
- The Closed State of the Thin Filament Is Not Occupied in Fully Activated Skeletal Muscle.Biophysical journal · 2017Article
- Cooperativity of myosin interaction with thin filaments is enhanced by stabilizing substitutions in tropomyosin.Journal of muscle research and cell motility · 2017Article
- Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling.Frontiers in physiology · 2016Article
- Direct Measurements of Local Coupling between Myosin Molecules Are Consistent with a Model of Muscle Activation.PLoS computational biology · 2015Article
- A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges.PLoS computational biology · 2015Article
- Stabilizing the central part of tropomyosin increases the bending stiffness of the thin filament.Biophysical journal · 2015Article
- Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids.Soft matter · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a model of Ca-regulated thin filaments in cardiac muscle where tropomyosin is treated as a continuous elastic chain confined in the closed position on the actin helix by electrostatic forces. The main distinction from previous works is that the intrinsic stress-free helical shape of the tropomyosin chain was taken into account explicitly. This results in the appearance of a new, to our knowledge, tension-like term in the energy functional and the equilibrium equation. The competitive binding of calcium and the mobile segment of troponin-I to troponin-C were described by a simple kinetic scheme. The values of dimensionless model parameters were estimated from published data. A stochastic Monte Carlo simulation of calcium curves has been performed and its results were compared to published data. The model explains the high cooperativity of calcium response of the regulated thin filaments even in the absence of myosin heads. The binding of myosin heads to actin increases the calcium sensitivity while not affecting its cooperativity significantly. When the presence of calcium-insensitive troponin-C was simulated in the model, both calcium sensitivity and cooperativity decreased. All these features were previously observed experimentally.
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