Evidence map›Paper›PMID 23972671›Full record

ArticleCancer epidemiology2013

Circulating levels of 25-hydroxyvitamin D and prostate cancer prognosis.

Sarah K Holt, Suzanne Kolb, Rong Fu, Ronald Horst, Ziding Feng, Janet L Stanford

Abstract read
In one paragraph

Article in Cancer epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Circulating 25-Hydroxyvitamin D and Prostate Cancer Survival.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016
    Trial
  3. Trial
  4. The double disparity: Vitamin D deficiency and lethal prostate cancer in black men.The Journal of steroid biochemistry and molecular biology · 2025
    Review
  5. Role of NOncology reports · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Vitamin D Receptor Signaling and Cancer.Endocrinology and metabolism clinics of North America · 2017
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah K HoltDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, United States. sholt@uw.edu
Suzanne Kolb
Rong Fu
Ronald Horst
Ziding Feng
Janet L Stanford

Funding

TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI RUTH D ETZIONI · 2002 to 2026
$58.1M
NSAIDS and Other Medications in Prostate Cancer EtiologyR01CA092579 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STANFORD, JANET L · 2001 to 2005
$3.2M
Plasma Vitamin D Levels and Prostate Cancer OutcomesR03CA153111 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STANFORD, JANET L · 2010 to 2011
$173k
PROSTATE CANCER IN RELATION TO VASECTOMYR01CA056678 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STANFORD, JANET L · 1993 to 1997
–
NCI NIH HHS P50 CA097186NCI NIH HHS P50-CA097186NCI NIH HHS R01 CA056678NCI NIH HHS R01- CA056678NCI NIH HHS R01 CA092579NCI NIH HHS R01-CA092579NCI NIH HHS R03 CA153111NCI NIH HHS R03-CA153111
6 · The paper itself

Abstract

objectivesEcological, in vitro, and in vivo studies demonstrate a link between vitamin D and prostate tumor growth and aggressiveness. The goal of this study was to investigate whether plasma concentration of vitamin D is associated with survivorship and disease progression in men diagnosed with prostate cancer. MATERIALS AND

methodsWe conducted a population-based cohort study of 1476 prostate cancer patients to assess disease recurrence/progression and prostate cancer-specific mortality (PCSM) risks associated with serum levels of 25(OH) vitamin D [25(OH)D].

resultsThere were 325 recurrence/progression and 95 PCSM events during an average of 10.8 years of follow-up. Serum levels of 25(OH)D were not associated with risk of recurrence/progression or mortality. Clinically deficient vitamin D levels were associated with an increased risk of death from other causes.

conclusionsWe did not find evidence that serum vitamin D levels measured after diagnosis affect prostate cancer prognosis. Lower levels of vitamin D were associated with risk of non-prostate cancer mortality.

Indexed as

AdultCohort StudiesDisease ProgressionFollow-Up StudiesHumansMaleMiddle AgedNeoplasm Recurrence, LocalProportional Hazards ModelsProspective StudiesProstatic NeoplasmsSEER ProgramVitamin DWashington25-hydroxyvitamin DVitamin D1,25-dihydroxyvitamin D(3)1,25(OH)(2)D25(OH)D25(OH) vitamin DADTandrogen deprivation therapyBMIbody mass indexCohort studiesEpidemiologic studiesFFQfood frequency questionnairehazard ratioHRHumansMaleMortalityPCaPCSMPHPrognosisproportional hazardsprostate cancerprostate cancer-specific mortalityprostate specific antigenProstatic neoplasmsPSAVitamin D/blood*

Identifiers

PMID23972671
PMCPMC3864767

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.