ArticleNeuron2013
A pair of interneurons influences the choice between feeding and locomotion in Drosophila.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism.Scientific reports · 2017Pooled it
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- Organization of an ascending circuit that conveys flight motor state in Drosophila.Current biology : CB · 2024Article
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- Organization of an Ascending Circuit that Conveys Flight Motor State.bioRxiv : the preprint server for biology · 2023Article
- A leaky integrate-and-fire computational model based on the connectome of the entire adultbioRxiv : the preprint server for biology · 2023Article
- Ascending neurons convey behavioral state to integrative sensory and action selection brain regions.Nature neuroscience · 2023Article
- Gustation in insects: taste qualities and types of evidence used to show taste function of specific body parts.Journal of insect science (Online) · 2023Article
- Neural Control of Action Selection Among Innate Behaviors.Neuroscience bulletin · 2022Review
- Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors.eLife · 2022Article
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- Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.Communications biology · 2021Article
- A neuronal mechanism controlling the choice between feeding and sexual behaviors in Drosophila.Current biology : CB · 2021Article
- Classification and genetic targeting of cell types in the primary taste and premotor center of the adulteLife · 2021Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit fly, Drosophila melanogaster, and identify a pair of interneurons in the ventral nerve cord that is activated by stimulation of mechanosensory neurons and inhibits feeding initiation, suggesting that these neurons suppress feeding while the fly is walking. Conversely, inhibiting activity in these neurons promotes feeding initiation and inhibits locomotion. These studies demonstrate the mutual exclusivity between locomotion and feeding initiation in the fly, isolate interneurons that influence this behavioral choice, and provide a framework for studying the neural basis for behavioral exclusivity in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.