Evidence map›Paper›PMID 23972592›Full record

ReviewNeuron2013

The sensory neurons of touch.

Victoria E Abraira, David D Ginty

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 726 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
726citing papers in PubMed, 2 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

726 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,543 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  7. Nonlinear distributed sensing of light patterns leads to perceptual distortions in plants.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  17. Immunopathogenesis of itch: an integrative framework for chronic pruritus.JID innovations : skin science from molecules to population health · 2026
    Review
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  20. Peripheral Neuropathy in Metabolic Stress.International journal of molecular sciences · 2026
    Review

666 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Victoria E AbrairaThe Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
David D Ginty
Howard Hughes Medical Institute · USJohns Hopkins University · US

Funding

Neuronal subtype-specific plasticity in the acute to chronic pain transitionR01DE022750 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CATERINA, MICHAEL J, DONG, XINZHONG · 2012 to 2016
$3.5M
Neurotrophin signals controlling development of the peripheral nervous systemR01NS034814 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GINTY, DAVID D · 1999 to 2015
$3.0M
Anatomical, physiological, and behavioral correlates of a C-LTMR circuitF32NS077836 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ABRAIRA, VICTORIA EUGENIA GUADALUPE · 2011 to 2013
$161k
Howard Hughes Medical InstituteNIDCR NIH HHS R01 5R01DE022750NIDCR NIH HHS R01 DE022750NINDS NIH HHS F32 NS077836NINDS NIH HHS F32NS077836-01NINDS NIH HHS R01 NS034814
6 · The paper itself

Abstract

The somatosensory system decodes a wide range of tactile stimuli and thus endows us with a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback and social exchange. The first step leading to perception of innocuous touch is activation of cutaneous sensory neurons called low-threshold mechanoreceptors (LTMRs). Here, we review the properties and functions of LTMRs, emphasizing the unique tuning properties of LTMR subtypes and the organizational logic of their peripheral and central axonal projections. We discuss the spinal cord neurophysiological representation of complex mechanical forces acting upon the skin and current views of how tactile information is processed and conveyed from the spinal cord to the brain. An integrative model in which ensembles of impulses arising from physiologically distinct LTMRs are integrated and processed in somatotopically aligned mechanosensory columns of the spinal cord dorsal horn underlies the nervous system's enormous capacity for perceiving the richness of the tactile world.

Indexed as

AnimalsMechanoreceptorsPhysical StimulationSensory Receptor CellsSensory ThresholdsTouch

Identifiers

PMID23972592
PMCPMC3811145
OpenAlexW2012265686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.