Evidence map›Paper›PMID 23972527›Full record

ArticleJournal of vascular surgery2014

Carotid stenting versus endarterectomy in patients undergoing reintervention after prior carotid endarterectomy.

Margriet Fokkema, Gert Jan de Borst, Brian W Nolan, Ruby C Lo, Robert A Cambria, Richard J Powell, Frans L Moll, Marc L Schermerhorn, Vascular Study Group of New England

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Carotid Endarterectomy: Current Concepts and Practice Patterns.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015
    Article
  9. Long-term Comparative Outcomes of Carotid Artery Stenting Following Previous Carotid Endarterectomy vs De Novo Lesions.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2015
    Article
  10. Clinical relevance of cranial nerve injury following carotid endarterectomy.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2014
    Article
  11. Carotid revascularization: risks and benefits.Vascular health and risk management · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Margriet FokkemaDepartment of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Gert Jan de BorstDepartment of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Brian W NolanSection of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Ruby C LoDepartment of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Robert A CambriaDepartment of Vascular Surgery, Eastern Maine Medical Center, Bangor, Me.
Richard J PowellSection of Vascular Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Frans L MollDepartment of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Marc L SchermerhornDepartment of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass. Electronic address: mscherme@bidmc.harvard.edu.
Vascular Study Group of New England
Dartmouth–Hitchcock Medical Center · USHadassah Medical Center · ILUtrecht University · NLBeth Israel Deaconess Medical Center · USEastern Maine Medical Center · US

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
NHLBI NIH HHS HL007734NHLBI NIH HHS T32 HL007734
6 · The paper itself

Abstract

backgroundOutcomes for patients undergoing intervention for restenosis after prior ipsilateral carotid endarterectomy (CEA) in the era of carotid angioplasty and stenting (CAS) are unclear. We compared perioperative results and durability of CAS vs CEA in patients with symptomatic or asymptomatic restenosis after prior CEA and investigated the risk of reintervention compared with primary procedures.

methodsPatients undergoing CAS and CEA for restenosis between January 2003 and March 2012 were identified within the Vascular Study Group of New England (VSGNE) database. End points included any stroke, death or myocardial infarction (MI) within 30 days, cranial nerve injury at discharge, and restenosis ≥ 70% at 1-year follow-up. Multivariable logistic regression was done to identify whether prior ipsilateral CEA was an independent predictor for adverse outcome.

resultsOut of 9305 CEA procedures, 212 patients (2.3%) underwent redo CEA (36% symptomatic). Of 663 CAS procedures, 220 patients (33%) underwent CAS after prior ipsilateral CEA (31% symptomatic). Demographics of patients undergoing redo CEA were comparable to patients undergoing CAS after prior CEA. Stroke/death/MI rates were statistically similar between redo CEA vs CAS after prior CEA in both asymptomatic (4.4% vs 3.3%; P = .8) and symptomatic patients (6.6% vs 5.8%; P = 1.0). No significant difference in restenosis ≥ 70% was identified between redo CEA and CAS after prior CEA (5.2% vs 3.0%; P = .5). Redo CEA vs primary CEA had increased stroke/death/MI rate in both symptomatic (6.6% vs 2.3%; P = .05) and asymptomatic patients 4.4% vs 1.7%; P = .03). Prior ipsilateral CEA was an independent predictor for stroke/death/MI among all patients undergoing CEA (odds ratio, 2.1; 95% confidence interval, 1.3-3.5). No difference in cranial nerve injury was identified between redo CEA and primary CEA (5.2% vs 4.7%; P = .8).

conclusionsIn the VSGNE, CEA and CAS showed statistically equivalent outcomes in asymptomatic and symptomatic patients treated for restenosis after prior ipsilateral CEA. However, regardless of symptom status, the risk of reintervention was increased compared with patients undergoing primary CEA.

Indexed as

Endarterectomy, CarotidStentsAgedAged, 80 and overAngioplastyAsymptomatic DiseasesCarotid Artery DiseasesFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNew EnglandOdds Ratio

Identifiers

PMID23972527
PMCPMC3852203
OpenAlexW2007883168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.