SynthesisRespiratory medicine2013
Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers.
Synthesis in Respiratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers.Respiratory medicine · 2013Pooled it
- Sex assigned at birth may modify health-related quality of life in children treated with peanut oral immunotherapy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Trial
- Sex-Based Disparities in Clinical Burden and Diagnostic Delay in COPD: Insights from Primary Care.Journal of clinical medicine · 2025Article
- Association between higher morning preference and better health-related quality of life in asthma.The journal of allergy and clinical immunology. Global · 2025Article
- An examination of factorial invariance of the Asthma Control Questionnaire among adults with severe asthma.PloS one · 2023Article
- Sex and Treatable Traits in Severe Asthma.Allergy, asthma & immunology research · 2021Article
- Minimal clinically important difference for asthma endpoints: an expert consensus report.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Gender Differences in Inhaled Pharmacotherapy Utilization in Patients with Obstructive Airway Diseases (OADs): A Population-Based Study.International journal of chronic obstructive pulmonary disease · 2020Article
- Gender differences in asthma perception and its impact on quality of life: a post hoc analysis of the PROXIMA (Patient Reported Outcomes and XolairAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Article
- Impact of increasing treatment rates on cost-effectiveness of subcutaneous immunotherapy (SCIT) in respiratory allergy: a decision analytic modelling approach.The European journal of health economics : HEPAC : health economics in prevention and care · 2018Article
- Depressive symptoms, quality of sleep, and disease control in women with asthma.Sleep & breathing = Schlaf & Atmung · 2017Article
- Gender aspects and influence of hormones on bronchial asthma - Secondary publication and update.The World Allergy Organization journal · 2017Review
- Post-menopausal Women Exhibit Greater Interleukin-6 Responses to Mental Stress Than Older Men.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Article
- Significant predictors of poor quality of life in older asthmatics.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015Article
- Asthma is Different in Women.Current allergy and asthma reports · 2015Review
- Clinical factors affecting discrepant correlation between asthma control test score and pulmonary function.Allergy, asthma & immunology research · 2015Article
- Gender differences in work-related asthma: surveillance data from California, Massachusetts, Michigan, and New Jersey, 1993-2008.The Journal of asthma : official journal of the Association for the Care of Asthma · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveImportant differences between men and women with asthma have been demonstrated, with women describing more symptoms and worse asthma-related quality of life (QOL) despite having similar or better pulmonary function. While current guidelines focus heavily on assessing asthma control, they lack information about whether sex-specific approaches to asthma assessment should be considered. We sought to determine if sex differences in asthma control or symptom profiles exist in the well-characterized population of participants in the American Lung Association Asthma Clinical Research Centers (ALA-ACRC) trials.
methodsWe reviewed baseline data from four trials published by the ALA-ACRC to evaluate individual item responses to three standardized asthma questionnaires: the Juniper Asthma Control Questionnaire (ACQ), the multi-attribute Asthma Symptom Utility Index (ASUI), and Juniper Mini Asthma Quality of Life Questionnaire (mini-AQLQ).
resultsIn the poorly-controlled population, women reported similar overall asthma control (mean ACQ 1.9 vs. 1.8; p = 0.54), but were more likely to report specific symptoms such as nocturnal awakenings, activity limitations, and shortness of breath on individual item responses. Women reported worse asthma-related QOL on the mini-AQLQ (mean 4.5 vs. 4.9; p < 0.001) and more asthma-related symptoms with a lower mean score on the ASUI (0.73 vs. 0.77; p ≤ 0.0001) and were more likely to report feeling bothered by particular symptoms such as coughing, or environmental triggers.
conclusionsIn participants with poorly-controlled asthma, women had outwardly similar asthma control, but had unique symptom profiles on detailed item analyses which were evident on evaluation of three standardized asthma questionnaires.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.