ReviewEarly human development2013
Viral bronchiolitis in children: a common condition with few therapeutic options.
Review in Early human development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Predictors of Inappropriate Use of Diagnostic Tests and Management of Bronchiolitis.BioMed research international · 2017Trial
- Characterizing the Genetics of Bronchiolitis by Viral Etiology: Is There a Shared Role in Asthma Development?The Journal of infectious diseases · 2025Article
- Pediatric Respiratory Infections After the COVID-19 Pandemic: A Single-Center Experience.Cureus · 2024Article
- Epidemiology and Risk Factor Analysis of Children with Bronchiolitis Admitted to the Intensive Care Unit at a Tertiary Care Center in Saudi Arabia.Children (Basel, Switzerland) · 2023Article
- When is asthma not guilty?International journal of pediatrics & adolescent medicine · 2021Review
- Clinical Epidemiological Characteristics and Risk Factors for Severe Bronchiolitis Caused by Respiratory Syncytial Virus in Vietnamese Children.International journal of pediatrics · 2021Article
- Parent Experiences Caring for a Child With Bronchiolitis: A Qualitative Study.Journal of patient experience · 2020Article
- Article
- Clinical definition of respiratory viral infections in young children and potential bronchiolitis misclassification.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2018Article
- Etiology and clinical features of viral bronchiolitis in infancy.World journal of pediatrics : WJP · 2017Review
- Bronchiolitis in children: The Saudi initiative of bronchiolitis diagnosis, management, and prevention (SIBRO).Annals of thoracic medicineArticle
- Characteristics and progression of children with acute viral bronchiolitis subjected to mechanical ventilation.Revista Brasileira de terapia intensivaArticle
- Saudi Initiative of Bronchiolitis Diagnosis, Management, and Prevention 2024 updated consensus on the prevention of respiratory syncytial virus.Annals of thoracic medicineArticle
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though bronchiolitis is a disease that has been recognized for many years, there are still few therapeutic strategies beyond supportive therapies. Bronchiolitis is the most frequent cause of hospital admission in children less than 1 year of age. The incidence is estimated to be about 150° million cases a year worldwide, and 2-3% of these cases require hospitalization. It is acknowledged that viruses cause bronchiolitis, but most of the studies focus on RSV. The RSV causes a more severe form of bronchiolitis in children with risk factors including prematurity, cardiovascular disease and immunodeficiency. Other viruses involved in causing bronchiolitis include RV, hMPV, hBoV and co-infections. The RV seems to be associated with a less severe acute disease, but there is a correlation between the early infection and subsequent wheezing bronchitis and asthma in later childhood and adulthood. The supportive therapies used are intravenous fluids and oxygen supplement administered by nasal cannula or CPAP in most complicated patients. Additional pharmacological therapies include epinephrine, 3% hypertonic saline and corticosteroids. The Epinephrine seems to have the greatest short-term benefits and reduces the need of hospital admission, whereas hypertonic saline and corticosteroids seem to reduce the length of hospital stay. As bronchiolitis is such a prevalent disease in children and RV seems to play an important role, perhaps more studies should center around the RV's contribution to the initial disease and following pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.