ArticleBMC gastroenterology2013
Gastro-oesophageal reflux disease in type 2 diabetics: symptom load and pathophysiologic aspects - a retro-pro study.
Article in BMC gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Metabolic syndrome is associated with increased risk of Barrett esophagus: A meta-analysis.Medicine · 2016Pooled it
- Type 2 Diabetes Mellitus andLife (Basel, Switzerland) · 2024Article
- Pre-operative bariatric patient characteristics driving hiatal hernia repair decision by operating surgeons.Surgery in practice and science · 2023Article
- Factors associated with gastro-duodenal ulcer in compensated type 2 diabetic patients: a Romanian single-center study.Archives of medical science : AMS · 2022Article
- Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Article
- Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients.PloS one · 2018Article
- Gastroesophageal reflux disease in patients with long standing type 1 diabetes mellitus: utility of two self-report questionnaires in a multifactorial disease.Colombia medica (Cali, Colombia) · 2017Article
- Prevalence and pattern of co morbidity among type2 diabetics attending urban primary healthcare centers at Bhubaneswar (India).PloS one · 2017Article
- Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion.Clinical diabetes : a publication of the American Diabetes Association · 2015Article
- Nonalcoholic fatty liver disease increases risk for gastroesophageal reflux symptoms.Digestive diseases and sciences · 2014Article
- The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome.International forum of allergy & rhinology · 2014Article
- Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis.PloS one · 2014Article
- Treating Diabetic Neuropathy: Present Strategies and Emerging Solutions.The review of diabetic studies : RDSReview
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInformation about gastro-oesophageal reflux disease (GERD) in patients with Diabetes mellitus type 2 (T2D) is scarce, although the incidence of both disorders is increasing.
methodsThis "retro-pro" study compared 65 T2D patients to a control group of 130 age- and sex-matched non-diabetics. GERD was confirmed by gastroscopy, manometry, pH-metry and barium swallow.
resultsIn patients with T2D compared to controls, dysphagia (32.3% vs. 13.1%; p = 0.001) and globus sensation (27.7% vs. 13.8%; p = 0.021) were found more frequently, whereas heartburn (76.9% vs. 88.5%; p = 0.046) and regurgitation (47.7% vs. 72.3%; p= 0.001) were predominant in non-diabetics. Despite higher body mass indices (31.1 ± 5.2 vs. 27.7 ± 3.7 kg/m²; p < 0.001), hiatal hernia was less frequent in T2D patients compared to controls (60.0% vs. 90.8%, p < 0.001). Lower oesophageal sphincter (LES) pressure was higher in patients with T2D (median 10.0 vs. 7.2 mmHg, p = 0.016). DeMeester scores did not differ between the groups. Helicobacter pylori infections were more common in T2D patients (26.2% vs. 7.7%, p = 0.001). Barrett metaplasia (21.5% vs. 17.7%), as well as low- (10.8% vs. 3.8%) and high-grade dysplasia (1.5% vs. 0%) were predominant in T2D patients.
conclusionsT2D patients exhibit different GERD symptoms, higher LES pressures and a decreased prevalence of hiatal hernia than non-diabetics, which may be related to worse oesophageal motility and, thus, a more functional rather than anatomical cause of GERD. Low-grade dysplasia was more than twice as high in T2D than in non-diabetics patients.
trial registrationEthics committee of the Medical University of Vienna, IRB number 720/2011.
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