ArticleChild neuropsychology : a journal on normal and abnormal development in childhood and adolescence2014
Postnatal exposure to methyl mercury and neuropsychological development in 7-year-old urban inner-city children exposed to lead in the United States.
Article in Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2.Neurotoxicology · 2023Article
- Impairment in Working Memory and Executive Function Associated with Mercury Exposure in Indigenous Populations in Upper Amazonian Peru.International journal of environmental research and public health · 2022Article
- Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption.Hormones and behavior · 2018Article
- Metabolomics of Pregnancy Complications: Emerging Application of Maternal Hair.BioMed research international · 2018Review
- Neurodevelopmental Effects of Mercury.Advances in neurotoxicology · 2018Article
- Biomonitoring of mercury, cadmium, and lead exposure in Japanese children: a cross-sectional study.Environmental health and preventive medicine · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe most common route for general population exposure to methyl mercury (MeHg) is fish consumption. Recommendations to pregnant women about consuming fish contaminated with MeHg are also applied to children, but there are few studies available about the effects of low-level postnatal MeHg exposure in them.
objectivesTo investigate the association between postnatal methyl mercury exposure and neuropsychological development in a study of children also exposed to lead, both measured at 7 years.
methodsWe measured MeHg concentrations in blood samples from the Treatment of Lead-Exposed Children (TLC) trial in which 780 children with elevated concentrations of lead in blood were followed with neuropsychological tests from ages 12-33 months through 7 years. Here we examine blood MeHg concentration and neuropsychological test scores, both measured at age 7 years. We used a maximum likelihood method to estimate geometric mean MeHg concentration and generalized linear regression models to analyze MeHg and neuropsychological test scores.
resultsGeometric mean MeHg concentration was 0.56 (95% confidence interval: 0.52, 0.59) μ g/L. A 1 μ g/L increase in MeHg was associated with a 2.1 (95% confidence interval: 0.4, 3.8) point increase in Full-Scale IQ and 0.2 (95% confidence interval: 0.02, 0.4) point increase in Learning Slopeindex T-score on a test of verbal memory.
conclusionsOur results suggest that the relatively low MeHg exposure in US school-aged children from this population has no detectable adverse effect on neuropsychological development. The positive associations observed between MeHg and neurodevelopment may indirectly reflect consumption of beneficial polyunsaturated fatty acids from seafood.
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