ArticleJournal of the American Chemical Society2013
Allosterically tunable, DNA-based switches triggered by heavy metals.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 114 citations in OpenAlex.
- An Intelligent Allosteric DNAzyme Platform for On-Site Uracil-DNA Glycosylase Imaging and On-Demand Gene Regulation.JACS Au · 2025Article
- Advancements and Prospects in DNA-Based Bioanalytical Technology for Environmental Toxicant Detection.JACS Au · 2025Review
- Portable Aptasensor Based on Parallel Rolling Circle Amplification for Tumor-Derived Exosomes Liquid Biopsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Label-free detection of biomolecules using inductively coupled plasma mass spectrometry (ICP-MS).Analytical and bioanalytical chemistry · 2024Review
- Self-Assembled DNA Machine and Selective Complexation Recognition Enable Rapid Homogeneous Portable Quantification of Lung Cancer CTCs.Research (Washington, D.C.) · 2024Article
- Functional advantages of building nanosystems using multiple molecular components.Nature chemistry · 2023Article
- Synthesizing the biochemical and semiconductor worlds:Nanoscale · 2022Review
- Programmable self-regulated molecular buffers for precise sustained drug delivery.Nature communications · 2022Article
- Advances in regenerative medicine applications of tetrahedral framework nucleic acid-based nanomaterials: an expert consensus recommendation.International journal of oral science · 2022Review
- A review on silver-mediated DNA base pairs: methodology and application.Biomaterials research · 2022Review
- Programmable allosteric DNA regulations for molecular networks and nanomachines.Science advances · 2022Article
- Stoichiometric approach to quantitative analysis of biomolecules: the case of nucleic acids.Analytical and bioanalytical chemistry · 2022Article
- Controllable DNA strand displacement by independent metal-ligand complexation.Chemical science · 2021Article
- Article
- Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes.Angewandte Chemie (International ed. in English) · 2021Article
- Synthetic Biology Enables Programmable Cell-Based Biosensors.Chemphyschem : a European journal of chemical physics and physical chemistry · 2020Review
- Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit.Nature communications · 2018Article
- Complementary oligonucleotides regulate induced fit ligand binding in duplexed aptamers.Chemical science · 2017Article
- Allosteric DNA nanoswitches for controlled release of a molecular cargo triggered by biological inputs.Chemical science · 2017Article
- Using Nature's "Tricks" To Rationally Tune the Binding Properties of Biomolecular Receptors.Accounts of chemical research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
Abstract
Here we demonstrate the rational design of allosterically controllable, metal-ion-triggered molecular switches. Specifically, we designed DNA sequences that adopt two low energy conformations, one of which does not bind to the target ion and the other of which contains mismatch sites serving as specific recognition elements for mercury(II) or silver(I) ions. Both switches contain multiple metal binding sites and thus exhibit homotropic allosteric (cooperative) responses. As heterotropic allosteric effectors we employ single-stranded DNA sequences that either stabilize or destabilize the nonbinding state, enabling dynamic range tuning over several orders of magnitude. The ability to rationally introduce these effects into target-responsive switches could be of value in improving the functionality of DNA-based nanomachines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.