ArticleBMC pulmonary medicine2013
Chronic obstructive pulmonary disease and exacerbations: patient insights from the global Hidden Depths of COPD survey.
Article in BMC pulmonary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05304494 (Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Proton pump inhibitors for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2020Pooled it
- Albuterol Digihaler in COPD Disease Management: A Real-World Study to Assess Digihaler Inhalation Parameters, Thresholds and Their Use to Identify Deterioration in Clinical Practice.International journal of chronic obstructive pulmonary disease · 2025Trial
- Exacerbation recovery patterns in newly diagnosed or maintenance treatment-naïve patients with COPD: secondary analyses of TICARI 1 trial data.International journal of chronic obstructive pulmonary disease · 2018Trial
- Salford Lung Study in chronic obstructive pulmonary disease (SLS COPD): follow-up interviews on patient-centred outcomes.NPJ primary care respiratory medicine · 2017Trial
- The Impact of Exacerbation History on the Safety and Efficacy of Aclidinium in Patients with Chronic Obstructive Pulmonary Disease and Increased Cardiovascular Risk: ASCENT-COPD Trial.International journal of chronic obstructive pulmonary diseaseTrial
- COPD Exacerbation Recognition Tool: Translation, Linguistic, and Cross-Cultural Validation.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- Can Patient Education Lead the Way? Head-To-Head Comparison of EXACT and CERT for Early Recognition of Acute COPD Exacerbations.Respirology (Carlton, Vic.) · 2026Article
- Validation and Clinical Analysis of the Quantitative COPD Exacerbation Recognition Tool (Q-CERT): Diagnostic Performance and Association with Lung Function Impairment.International journal of chronic obstructive pulmonary disease · 2026Article
- Clinical Meaningfulness of the Composite Endpoint, COPDCompEx, in Defining Exacerbations and Worsening of COPD: A Post Hoc Analysis of 4 Clinical Interventional Studies of COPD.International journal of chronic obstructive pulmonary disease · 2026Article
- Incidence of acute exacerbations of chronic respiratory disease during pulmonary rehabilitation delivered at home or hospital.ERJ open research · 2025Article
- Breaking down barriers to COPD management in primary care: applying the updated 2023 Canadian Thoracic Society guideline for pharmacotherapy.Frontiers in medicine · 2024Review
- Pulmonary Function and Quality of Life in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.AIDS research and human retroviruses · 2023Article
- Giving Voice to People - Experiences During Mild to Moderate Acute Exacerbations of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- Relationship between risk, cumulative burden of exacerbations and mortality in patients with COPD: modelling analysis using data from the ETHOS study.BMC medical research methodology · 2022Article
- COPD - do the right thing.BMC family practice · 2021Review
- Economic Burden of Chronic Obstructive Pulmonary Disease Patients in Malaysia: A Longitudinal Study.PharmacoEconomics - open · 2021Article
- A Nomogram for Predicting Severe Exacerbations in Stable COPD Patients.International journal of chronic obstructive pulmonary disease · 2020Observational
- Technology-Enabled Self-Monitoring of Chronic Obstructive Pulmonary Disease With or Without Asynchronous Remote Monitoring: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2019Article
- Statins versus placebo for people with chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough chronic obstructive pulmonary disease (COPD) is a major global health burden there is a lack of patient awareness of disease severity, particularly in relation to exacerbations.
methodsWe conducted a global patient survey using an innovative, internet-based methodology to gain insight into patient perceptions of COPD and exacerbations in a real-world sample typical of today's working-age COPD population.
resultsTwo thousand patients with COPD (53%), chronic bronchitis (52%) and/or emphysema (22%) from 14 countries completed an online questionnaire developed by the authors. The Medical Research Council (MRC) breathlessness scale was used to delineate symptom severity. Over three quarters of patients (77%) had experienced an exacerbation, with 27% of MRC 1 and 2 patients and 52% of MRC 3, 4 and 5 patients requiring hospitalization as a result of an exacerbation. While a majority of MRC 1 and 2 patients (51%) reported being back to normal within a few days of an exacerbation, 23% of MRC 3, 4 and 5 patients took several weeks to return to normal and 6% never fully recovered. A high proportion of patients (39%) took a 'wait and see' approach to exacerbations.Despite the high prevalence of exacerbations and their negative impact on quality of life, 73% of MRC 1 and 2 patients and 64% of MRC 3, 4 and 5 patients felt that they had control of their COPD. However, 77% of all patients were worried about their long-term health, and 38% of MRC 1 and 2 patients and 59% of MRC 3, 4 and 5 patients feared premature death due to COPD.
conclusionsTo reduce the adverse effects of COPD on patients' quality of life and address their fears for the future, we need better patient education and improved prevention and treatment of exacerbations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.