ReviewBioMed research international2013
The age-related changes in cartilage and osteoarthritis.
Review in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03974308 (Effectiveness of Spa Treatment in Patients With Spine Osteoarthritis in Comparison With Outpatient Physiotherapy and no Physiotherapy), which is not on this map. Cited by 100 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Spa Treatment in Patients With Spine Osteoarthritis in Comparison With Outpatient Physiotherapy and no Physiotherapy
Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 190 citations in OpenAlex.
- Prevalence of knee osteoarthritis in the Chinese population, 2013-2023: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (OClinical rheumatology · 2018Trial
- One-Year Follow-Up of Spa Treatment in Older Patients with Osteoarthritis: A Prospective, Single Group Study.BioMed research international · 2018Trial
- Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint.Molecular and cellular biochemistry · 2017Trial
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Advanced glycation end product accumulation and AGEs-RAGE axis biomarkers in plasma and synovial fluid are associated with osteoarthritis severity.Biomolecules & biomedicine · 2026Observational
- Association of latent class trajectories of frailty with incident symptomatic knee osteoarthritis in Chinese postmenopausal women: a nationwide cohort study from China.Scientific reports · 2026Article
- Distinct Responses of Estrogen Receptor α and β in Chondrocytes Under Excessive Mechanical Stress.Cartilage · 2026Article
- Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1.Expert review of clinical pharmacology · 2026Review
- Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.GeroScience · 2026Review
- The effect of spaceflight on tissues of the spinal column.Bone reports · 2026Review
- Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging.Bone research · 2026Article
- [Analysis of current status and trends of disease burden of knee osteoarthritis in China, 1990-2023].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- Dual-energy computed tomography collagen density mapping of the temporomandibular disc.BMC medical imaging · 2025Article
- Characterization of the Age-Related Differences in Porcine Acetabulum and Femoral Head Articular Cartilage.Cartilage · 2025Article
- Morphometric assessment of the patella in healthy, chondromalacia and meniscopathy individuals: a retrospective study.BMC musculoskeletal disorders · 2025Article
- Generation of an In Vitro Cartilage Aging Model Using Human Sera from Old Donors.Bioengineering (Basel, Switzerland) · 2025Article
- Classification of Grades of Subchondral Sclerosis from Knee Radiographic Images Using Artificial Intelligence.Sensors (Basel, Switzerland) · 2025Article
- The Emerging Role of Water Loss in Dog Aging.Cells · 2025Review
- [Risk and complication profiles of orthogeriatric patients in elective hip and knee joint replacement].Zeitschrift fur Gerontologie und Geriatrie · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Osteoarthritis (OA) is closely associated with aging, but its underlying mechanism is unclear. Recent publications were reviewed to elucidate the connection between aging and OA. With increasing OA incidence, more senior people are facing heavy financial and social burdens. Age-related OA pathogenesis is not well understood. Recently, it has been realized that age-related changes in other tissues besides articular cartilage may also contribute to OA development. Many factors including senescence-related secretory phenotypes, chondrocytes' low reactivity to growth factors, mitochondrial dysfunction and oxidative stress, and abnormal accumulation of advanced glycation end products (AGEs) may all play key roles in the pathogenesis of age-related OA. Lately, epigenetic regulation of gene expression was recognized for its impact on age-related OA pathogenesis. Up to now, few studies have been reported about the role of miRNA and long-noncoding RNA (lncRNA) in age-related OA. Research focusing on this area may provide valuable insights into OA pathogenesis. OA-induced financial and social burdens have become an increasingly severe threat to older population. Age-related changes in noncartilage tissue should be incorporated in the understanding of OA development. Growing attention on oxidative stress and epigenetics will provide more important clues for the better understanding of the age-related OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.