ReviewNeural plasticity2013
Environment, leptin sensitivity, and hypothalamic plasticity.
Review in Neural plasticity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Effects of Essential Oils and Fragrant Compounds on Appetite: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial.Neural plasticity · 2018Trial
- Nutritional state-dependent changes in subcortical limbic structures in anorexia nervosa are linked to leptin, ghrelin, and neurofilament light.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Effects of early life adversity on acute metabolic outcomes during neonatal development.Neurobiology of stress · 2026Article
- The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Reprogramming energy homeostasis in children with overweight through cognitive training and social interaction. A study protocol to estimate leptin sensitivity.Frontiers in endocrinology · 2025Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Effect of fasting on short-term visual plasticity in adult humans.The European journal of neuroscience · 2023Article
- Leptin, the brain and energy homeostasis: From an apparently simple to a highly complex neuronal system.Reviews in endocrine & metabolic disorders · 2022Review
- STAT3 phosphorylation in central leptin resistance.Nutrition & metabolism · 2021Review
- Leptin and Obesity: Role and Clinical Implication.Frontiers in endocrinology · 2021Review
- The Effect of Exogenous Ketone Monoester Ingestion on Plasma BDNF During an Oral Glucose Tolerance Test.Frontiers in physiology · 2020Article
- Editorial: Metabolic Mediators and Synapses: Linking Body Periphery to Neural Plasticity.Frontiers in cellular neuroscience · 2019Article
- Leptin resistance: underlying mechanisms and diagnosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF.Scientific reports · 2018Article
- Loss of Leptin-Induced Modulation of Hippocampal Synaptic Trasmission and Signal Transduction in High-Fat Diet-Fed Mice.Frontiers in cellular neuroscience · 2017Article
- Editorial: Leptin Resistance in Metabolic Disorders: Possible Mechanisms and Treatments.Frontiers in endocrinology · 2017Article
- The Effects of Leptin Replacement on Neural Plasticity.Neural plasticity · 2016Review
- Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats.Toxicology and applied pharmacology · 2015Article
- Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways.Journal of endocrinological investigation · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Regulation of feeding behavior has been a crucial step in the interplay between leptin and the arcuate nucleus of the hypothalamus (ARC). On one hand, the basic mechanisms regulating central and peripheral action of leptin are becoming increasingly clear. On the other hand, knowledge on how brain sensitivity to leptin can be modulated is only beginning to accumulate. This point is of paramount importance if one considers that pathologically obese subjects have high levels of plasmatic leptin. A possible strategy for exploring neural plasticity in the ARC is to act on environmental stimuli. This can be achieved with various protocols, namely, physical exercise, high-fat diet, caloric restriction, and environmental enrichment. Use of these protocols can, in turn, be exploited to isolate key molecules with translational potential. In the present review, we summarize present knowledge about the mechanisms of plasticity induced by the environment in the ARC. In addition, we also address the role of leptin in extrahypothalamic plasticity, in order to propose an integrated view of how a single diffusible factor can regulate diverse brain functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.