ArticlePathobiology of aging & age related diseases2013
Pathology is a critical aspect of preclinical aging studies.
Article in Pathobiology of aging & age related diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Histopathologic Evaluation and Scoring of Viral Lung Infection.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Principles and approaches for reproducible scoring of tissue stains in research.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Approaches to Evaluate Lung Inflammation in Translational Research.Veterinary pathology · 2018Review
- A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.Veterinary pathology · 2016Article
- Pathology assessment is necessary to validate translational endpoints in preclinical aging studies.Pathobiology of aging & age related diseases · 2016Article
- Integrating pathology into human disease modelling--how to eat the elephant.Disease models & mechanisms · 2014Article
- Reward components of feeding behavior are preserved during mouse aging.Frontiers in aging neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Experimental design for mouse aging studies has historically involved lifespan, but it is now clear that survival data without pathology data limit the information that can be obtained on aging animals. This limitation becomes more serious when interventions of any sort are implemented. Pathology gives an insight into the health of an animal by revealing lesions not readily observable in the live animal. As such, it is a snapshot of disease conditions at the time of death. Therefore, a long-term goal is to establish pathology information as an essential component of studies involving health span and lifespan of aging animals. Given that pathology assessment is essential to help define the progression of lesions associated with aging, the real challenge is including it in aging studies because there is currently a lack of specialized expertise and resources. An increase in the level and scope of pathology assessment of tissues from old mice involved in aging studies is needed. A focus on the correlation of pathology data with longitudinal and cross-sectional lifespan data and health span physiology data can be established by enhancing standard histologic assessment of lesions observed in tissues from old mice. An environment for the development and integration of pathology data into aging studies of mice is needed to encourage more pathologists and other scientists to specialize in pathology of aging, and establish relevant standards to compare with other species including humans. Such results will have an important positive impact on aging studies because of the significant empowerment on data analyses and interpretation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.