ArticleFrontiers in immunology2013
NLRP7 and the Genetics of Hydatidiform Moles: Recent Advances and New Challenges.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Magnitude and histopathological patterns of gestational trophoblastic disease in Africa: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Molecular Changes on Maternal-Fetal Interface in Placental Abruption-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Review
- Gestational Trophoblastic Disease: Diagnostic and Therapeutic Updates in Light of Recent Evidence: A Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Association of extended culture to blastocyst and pre-malignant gestational trophoblastic disease risk following IVF/ICSI-assisted reproduction cycles: an analysis of large UK national database.Journal of assisted reproduction and genetics · 2022Article
- Role of NLRP7 in Normal and Malignant Trophoblast Cells.Biomedicines · 2022Review
- Advances in the diagnosis and early management of gestational trophoblastic disease.BMJ medicine · 2022Review
- High-Risk Gestational Trophoblastic Neoplasia from a Homozygous NLRP7 Mutation.Gynecologic oncology reports · 2021Article
- Variants in Maternal Effect Genes and Relaxed Imprinting Control in a Special Placental Mesenchymal Dysplasia Case with Mild Trophoblast Hyperplasia.Biomedicines · 2021Article
- Pregnancy after oocyte donation in a patient with NLRP7 gene mutations and recurrent molar hydatidiform pregnancies.Journal of assisted reproduction and genetics · 2020Article
- Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome.Frontiers in immunology · 2020Article
- Article
- NLRP7 is expressed in the ovine ovary and associated with in vitro pre-implantation embryo development.Reproduction (Cambridge, England) · 2019Article
- Hepatic toxicity following actinomycin D chemotherapy in treatment of familial gestational trophoblastic neoplasia: A case report.Medicine · 2018Article
- Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review.Journal of assisted reproduction and genetics · 2018Review
- Maternal heterozygous NLRP7 variant results in recurrent reproductive failure and imprinting disturbances in the offspring.European journal of human genetics : EJHG · 2017Article
- Inflammasomes in Myeloid Cells: Warriors Within.Microbiology spectrum · 2017Review
- The hydatidiform mole.Cell adhesion & migration · 2016Review
- How Mouse Macrophages Sense What Is Going On.Frontiers in immunology · 2016Review
- Editorial: NLR-Protein Functions in Immunity.Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NOD-like receptor proteins (NLRPs) are emerging key players in several inflammatory pathways in Mammals. The first identified gene coding for a protein from this family is Nlrp5 and was originally called Mater for "Maternal Antigen That Mouse Embryos Require" for normal development beyond the two-cell stage. This important discovery was followed by the identification of other NLRPs playing roles in inflammatory disorders and of the first maternal-effect gene in humans, NLRP7, which is responsible for an aberrant form of human pregnancy called hydatidiform mole (HM). In this review, we recapitulate the various aspects of the pathology of HM, highlight recent advances regarding NLRP7 and its role in HM and related forms of reproductive losses, and expand our discussion to other NLRPs with a special emphasis on those with known roles in mammalian reproduction. Our aim is to facilitate the genetic complexity of recurrent fetal loss in humans and encourage interdisciplinary collaborations in the fields of NLRPs and reproductive loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.