ArticleFrontiers in microbiology2013
Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains.
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Helicobacter pylori-activated fibroblasts as a silent partner in gastric cancer development.Cancer metastasis reviews · 2023Review
- MicroRNA-5112 Targets IKKγ to Dampen the Inflammatory Response and Improve Clinical Symptoms in Both Bacterial Infection and DSS-Induced Colitis.Frontiers in immunology · 2022Article
- Statins' Regulation of the Virulence Factors ofAntioxidants (Basel, Switzerland) · 2021Review
- Helicobacter-stimulated IL-10-producing B cells suppress differentiation of lipopolysaccharide/Helicobacter felis-activated stimulatory dendritic cells.Turkish journal of biology = Turk biyoloji dergisi · 2021Article
- Transcriptomic microRNA Profiling of Dendritic Cells in Response to Gut Microbiota-Secreted Vesicles.Cells · 2020Article
- TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release ofInternational journal of molecular sciences · 2020Article
- Deregulation of miRNA inJournal of clinical medicine · 2019Article
- MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells.Leukemia · 2018Article
- Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor.Emerging microbes & infections · 2018Article
- Article
- Role of MicroRNA in the Lung's Innate Immune Response.Journal of innate immunity · 2017Review
- Deregulation of MicroRNAs in Gastric Lymphomagenesis Induced in the d3Tx Mouse Model ofFrontiers in cellular and infection microbiology · 2017Article
- Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection.Cellular microbiology · 2016Article
- Characterisation of inflammatory processes in Helicobacter pylori-induced gastric lymphomagenesis in a mouse model.Oncotarget · 2015Article
- Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions.World journal of clinical oncology · 2015Review
- Inflammatory response of macrophages cultured with Helicobacter pylori strains was regulated by miR-155.International journal of clinical and experimental pathology · 2015Article
- Correlation Between IL-10 and microRNA-187 Expression in Epileptic Rat Hippocampus and Patients with Temporal Lobe Epilepsy.Frontiers in cellular neuroscience · 2015Article
- Helicobacter pylori inhibits dendritic cell maturation via interleukin-10-mediated activation of the signal transducer and activator of transcription 3 pathway.Journal of innate immunity · 2015Article
- Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell-mediated parasite elimination.Autophagy · 2015Article
- Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs.World journal of gastroenterology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary human dendritic cells (DC) were used to explore the inflammatory effectors, including cytokines and microRNAs, regulated by Helicobacter pylori. In a 48 h ex-vivo co-culture system, both H. pylori B38 and B45 strains activated human DCs and promoted a strong inflammatory response characterized by the early production of pro-inflammatory TNFα and IL-6 cytokines, followed by IL-10, IL-1β, and IL-23 secretion. IL-23 was the only cytokine dependent on the cag pathogenicity island status of the bacterial strains. DC activation and cytokine production were accompanied by an early miR-146a upregulation followed by a strong miR-155 induction, which mainly controlled TNFα production. These results pave the way for further investigations into the nature of H. pylori antigens and the subsequently activated signaling pathways involved in the inflammatory response to H. pylori infection, the deregulation of which may likely contribute to gastric lymphomagenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.