ArticleFrontiers in neural circuits2013
Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Self-timed movement initiation requires rapid sequential coordination of circuits in prefrontal cortex and cerebellum.bioRxiv : the preprint server for biology · 2026Article
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1.Current biology : CB · 2026Article
- Cerebellar acceleration of learning in an evidence-accumulation task.Cell reports · 2026Article
- Homeostatic bidirectional plasticity in upbound and downbound micromodules in a model of the olivocerebellar loop.PLoS computational biology · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- How and where Effectively Apply Cerebellum Stimulation: The frequency-dependent Modulation of Cerebellar Output by Transcranial Alternating Current Stimulation.Cerebellum (London, England) · 2025Article
- The cerebellum engages multiple pre-motor pathways through a divergent-convergent architecture to shape whisker dynamics.Frontiers in neural circuits · 2025Article
- Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.Journal of neural engineering · 2024Article
- Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model.Protein & cell · 2024Article
- Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents.Cells · 2024Review
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Synaptic mechanisms for associative learning in the cerebellar nuclei.Nature communications · 2023Article
- Synaptic variance and action potential firing of cerebellar output neurons during motor learning in larval zebrafish.Current biology : CB · 2023Article
- Development, circuitry, and function of the zebrafish cerebellum.Cellular and molecular life sciences : CMLS · 2023Review
- Article
- Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz.Biomedicines · 2022Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum refines the accuracy and timing of motor performance. How it encodes information to perform these functions is a major topic of interest. We performed whole cell and extracellular recordings of Purkinje cells (PCs) and cerebellar nuclei neurons (CNs) in vivo, while activating PCs with light in transgenic mice. We show for the first time that graded activation of PCs translates into proportional CN inhibition and induces rebound activity in CNs, which is followed by graded motor contractions timed to the cessation of the stimulus. Moreover, activation of PC ensembles led to disinhibition of climbing fiber activity, which coincided with rebound activity in CNs. Our data indicate that cessation of concerted activity in ensembles of PCs can regulate both timing and strength of movements via control of rebound activity in CNs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.