ArticleFrontiers in molecular neuroscience2013
Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.
Article in Frontiers in molecular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics.Nature communications · 2024Article
- Tracking connectivity maps in human stem cell-derived neuronal networks by holographic optogenetics.Life science alliance · 2022Article
- Optogenetic control of cancer cell survival in ChR2-transfected HeLa cells.International journal of experimental pathology · 2021Article
- Optogenetically Controlled Activity Pattern Determines Survival Rate of Developing Neocortical Neurons.International journal of molecular sciences · 2021Article
- Optogenetic entrainment of neural oscillations with hybrid fiber probes.Journal of neural engineering · 2018Article
- Optogenetic Peripheral Nerve Immunogenicity.Scientific reports · 2018Article
- Fast wide-volume functional imaging of engineered in vitro brain tissues.Scientific reports · 2017Article
- Micromachining on and of Transparent Polymers for Patterning Electrodes and Growing Electrically Active Cells for Biosensor Applications.Micromachines · 2017Article
- Multichannel activity propagation across an engineered axon network.Journal of neural engineering · 2017Article
- And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation.Frontiers in neuroscience · 2017Review
- Maintaining ocular safety with light exposure, focusing on devices for optogenetic stimulation.Vision research · 2016Article
- An integrated multi-electrode-optrode array for in vitro optogenetics.Scientific reports · 2016Article
- Compartmentalized Platforms for Neuro-Pharmacological Research.Current neuropharmacology · 2016Review
- A low-noise, modular, and versatile analog front-end intended for processing in vitro neuronal signals detected by microelectrode arrays.Computational intelligence and neuroscience · 2015Article
- Optogenetic stimulation of the auditory pathway.The Journal of clinical investigation · 2014Article
- Timing matters: using optogenetics to chronically manipulate neural circuitry and rhythms.Frontiers in behavioral neuroscience · 2014Review
- Molecular probes and switches for functional analysis of receptors, ion channels and synaptic networks.Frontiers in molecular neuroscience · 2013Article
- Article
- Secreted Reporter Assay Enables Quantitative and Longitudinal Monitoring of Neuronal Activity.eNeuroArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal plasticity produces changes in excitability, synaptic transmission, and network architecture in response to external stimuli. Network adaptation to environmental conditions takes place in time scales ranging from few seconds to days, and modulates the entire network dynamics. To study the network response to defined long-term experimental protocols, we setup a system that combines optical and electrophysiological tools embedded in a cell incubator. Primary hippocampal neurons transduced with lentiviruses expressing channelrhodopsin-2/H134R were subjected to various photostimulation protocols in a time window in the order of days. To monitor the effects of light-induced gating of network activity, stimulated transduced neurons were simultaneously recorded using multi-electrode arrays (MEAs). The developed experimental model allows discerning short-term, long-lasting, and adaptive plasticity responses of the same neuronal network to distinct stimulation frequencies applied over different temporal windows.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.