ArticleSchizophrenia bulletin2014
Molecular validation of the schizophrenia spectrum.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems.The American journal of psychiatry · 2019Pooled it
- Meta-analysis of Positive and Negative Symptoms Reveals Schizophrenia Modifier Genes.Schizophrenia bulletin · 2016Pooled it
- Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.Nature communications · 2015Pooled it
- Rare Copy Number Variation in Schizophrenia and Implications for Treatment.Schizophrenia bulletin · 2023Article
- Visual masking deficits in schizophrenia: a view into the genetics of the disease through an endophenotype.Translational psychiatry · 2022Article
- Examining the source of increased bipolar disorder and major depressive disorder common risk variation burden in multiplex schizophrenia families.Schizophrenia (Heidelberg, Germany) · 2022Article
- Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.JAMA psychiatry · 2022Article
- Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families.Translational psychiatry · 2022Article
- Psychometric properties of Drug Attitude Inventory among patients with schizophrenia.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2022Review
- Schizophrenia-spectrum psychopathology in obsessive-compulsive disorder: an empirical study.European archives of psychiatry and clinical neuroscience · 2020Article
- Discovery of rare variants implicated in schizophrenia using next-generation sequencing.Journal of translational genetics and genomics · 2019Article
- Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative.Schizophrenia bulletin · 2018Article
- Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.The British journal of psychiatry : the journal of mental science · 2018Article
- Assessing the evidence for shared genetic risks across psychiatric disorders and traits.Psychological medicine · 2018Review
- Genetics of Schizophrenia: Overview of Methods, Findings and Limitations.Frontiers in human neuroscience · 2017Review
- White matter correlates of psychosis-linked traits support continuity between personality and psychopathology.Journal of abnormal psychology · 2016Article
- Familiality of Psychotic Disorders: A Polynosologic Study in Multiplex Families.Schizophrenia bulletin · 2016Article
- Psychosis as a continuous phenotype in the general population: the thin line between normality and pathology.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- New statistical approaches exploit the polygenic architecture of schizophrenia--implications for the underlying neurobiology.Current opinion in neurobiology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundEarly descriptive work and controlled family and adoption studies support the hypothesis that a range of personality and nonschizophrenic psychotic disorders aggregate in families of schizophrenic probands. Can we validate, using molecular polygene scores from genome-wide association studies (GWAS), this schizophrenia spectrum?
methodsThe predictive value of polygenic findings reported by the Psychiatric GWAS Consortium (PGC) was applied to 4 groups of relatives from the Irish Study of High-Density Schizophrenia Families (ISHDSF; N = 836) differing on their assignment within the schizophrenia spectrum. Genome-wide single nucleotide polymorphism data for affected and unaffected relatives were used to construct per-individual polygene risk scores based on the PGC stage-I results. We compared mean polygene scores in the ISHDSF with mean scores in ethnically matched population controls (N = 929).
resultsThe schizophrenia polygene score differed significantly across diagnostic categories and was highest in those with narrow schizophrenia spectrum, lowest in those with no psychiatric illness, and in-between in those classified in the intermediate, broad, and very broad schizophrenia spectrum. Relatives of all of these groups of affected subjects, including those with no diagnosis, had schizophrenia polygene scores significantly higher than the control sample.
conclusionsIn the relatives of high-density families, the observed pattern of enrichment of molecular indices of schizophrenia risk suggests an underlying, continuous liability distribution and validates, using aggregate common risk alleles, a genetic basis for the schizophrenia spectrum disorders. In addition, as predicted by genetic theory, nonpsychotic members of multiply-affected schizophrenia families are significantly enriched for replicated, polygenic risk variants compared with the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.