ArticleAntiviral therapy2014
Does HIV infection promote early kidney injury in women?
Article in Antiviral therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function.Archives of medical science : AMS · 2023Article
- Soluble Insulin Receptor Levels in Plasma, Exosomes, and Urine and Its Association With HIV-Associated Neurocognitive Disorders.Frontiers in neurology · 2022Article
- Urinary biomarkers of early renal injury in antiretroviral-naïve HIV-positive persons in Shanghai, China: comparison with the general population.HIV medicine · 2021Article
- Kidney tubule health scores and their associations with incident CKD in women living with HIV.HIV medicine · 2021Article
- Profiling Biomarkers in HIV Glomerular Disease - Potential for the Non-Invasive Diagnosis of HIVAN?International journal of nephrology and renovascular disease · 2021Article
- Association of Statin Use With Kidney Damage and Function Among HIV-Infected Men.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Biomarkers of Acute and Chronic Kidney Disease.Annual review of physiology · 2019Review
- Kidney disease risk factors associate with urine biomarkers concentrations in HIV-positive persons; a cross-sectional study.BMC nephrology · 2019Article
- Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men.American journal of nephrology · 2019Article
- Changes in Urinary Biomarkers Over 10 Years Is Associated With Viral Suppression in a Prospective Cohort of Women Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study.Antiviral therapy · 2017Article
- Urinary Markers of Tubular Injury in HIV-Infected Patients.Biochemistry research international · 2016Review
- APOL1 Genotype and Glomerular and Tubular Kidney Injury in Women With HIV.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Observational
- Association of urine α1-microglobulin with kidney function decline and mortality in HIV-infected women.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Albuminuria Is Associated with Traditional Cardiovascular Risk Factors and Viral Load in HIV-Infected Patients in Rural South Africa.PloS one · 2015Article
- Urine Biomarkers of Kidney Tubule Health and Incident CKD Stage 3 in Women Living With HIV: A Repeated Measures Study.Kidney medicineArticle
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundIn HIV-infected women, urine concentrations of novel tubulointerstitial injury markers, interleukin-18 (IL-18) and kidney injury marker-1 (KIM-1), are associated with kidney function decline and all-cause mortality. We hypothesized that HIV-infected individuals with preserved kidney filtration function would have more extensive kidney injury, as determined by urine injury markers, compared to the uninfected controls, and that risk factors for tubulointerstitial injury would differ from risk factors for albuminuria.
methodsIn this cross-sectional study, we compared urine concentrations of IL-18, KIM-1 and albumin-to-creatinine ratio (ACR) in 908 HIV-infected and 289 HIV-uninfected women enrolled in the Women's Interagency HIV Study, utilizing stored urine specimens from visits between 1999 and 2000.
resultsAfter multivariate-adjusted linear regression analysis, mean urine concentrations were higher in HIV-infected individuals by 38% for IL-18 (P<0.0001), 12% for KIM-1 (P=0.081) and 47% for ACR (P<0.0001). Higher HIV RNA level (15% per 10-fold increase; P<0.0001), lower CD4(+) lymphocyte count (8% per doubling; P=0.0025), HCV infection (30%; P=0.00018) and lower high-density lipoprotein (5% per 10 mg/dl; P=0.0024) were each associated with higher IL-18 concentrations. In contrast, hypertension (81%; P<0.0001) and diabetes (47%; P=0.018) were among the strongest predictors of higher ACR, though HIV RNA level (15% per 10-fold increase; P=0.0004) was also associated with higher ACR.
conclusionsHIV-infected women had more extensive tubulointerstitial and glomerular injury than uninfected women, but the associated factors differed among the urine biomarkers. Combinations of urinary biomarkers should be investigated to further characterize early kidney injury in HIV-infected women.
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