ArticleScientific reports2013
Direct characterization of bulk samples by internal extractive electrospray ionization mass spectrometry.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Rapid discrimination of human oesophageal squamous cell carcinoma by mass spectrometry based on differences in amino acid metabolism.Scientific reports · 2017Trial
- Tissue spray ionization mass spectrometry for rapid recognition of human lung squamous cell carcinoma.Scientific reports · 2015Trial
- Research Progress on Extraction and Detection Technologies of Flavonoid Compounds in Foods.Foods (Basel, Switzerland) · 2024Review
- Metabolite Fingerprinting for Identification ofFoods (Basel, Switzerland) · 2023Article
- Advances in Ultra-High-Resolution Mass Spectrometry for Pharmaceutical Analysis.Molecules (Basel, Switzerland) · 2023Review
- Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals.Frontiers in pharmacology · 2023Review
- Neutral Desorption Extractive Electrospray Ionization Mass Spectrometry Analysis Sputum for Non-Invasive Lung Adenocarcinoma Detection.OncoTargets and therapy · 2021Article
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- Lipids in surgical aerosol as diagnosis biomarkers for discrimination of lung cancer.Cancer management and research · 2019Article
- Investigation Of Small Molecular Substances As Potential Biomarkers For Discrimination Of Gastric Tumor.OncoTargets and therapy · 2019Article
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- A Comparison of Tissue Spray and Lipid Extract Direct Injection Electrospray Ionization Mass Spectrometry for the Differentiation of Eutopic and Ectopic Endometrial Tissues.Journal of the American Society for Mass Spectrometry · 2018Article
- Internal Extractive Electrospray Ionization Mass Spectrometry for Quantitative Determination of Fluoroquinolones Captured by Magnetic Molecularly Imprinted Polymers from Raw Milk.Scientific reports · 2017Article
- Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry.Scientific reports · 2017Article
- Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry.Scientific reports · 2017Article
- Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry.Scientific reports · 2016Article
- Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real-Time Chemical Analysis.Mass spectrometry reviewsReview
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A straight-forward analytical strategy called internal extractive electrospray ionization mass spectrometry (iEESI-MS), which combines solvent extraction of chemicals inside a bulk sample with in situ electrospray ionization mass spectrometry, has been established to directly characterize the interior of a bulk sample with molecular specificity. The method allows both qualitative and quantitative analysis of analytes distributed in a 3-dimensional volume (e.g., 1 ~ 100 mm(3)) of various synthetic and biological matrices (e.g., chewing gum, leaves, fruits, roots, pork, lung tissues) without either mashing the sample or matrix separation. Using different extraction solvents, online chromatographic separation of chemicals inside the sample volume was observed during iEESI-MS analysis. The presented method is featured by the high speed of analysis, high sensitivity, low sample consumption and minimal sample preparation and/or degradation, offering unique possibilities for advanced applications in plant science, clinical diagnosis, catalyst studies, and materials science.
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