ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2013
Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Using proton pump inhibitors increases the risk of hepato-biliary-pancreatic cancer. A systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Article
- Temporality of clinical factors associated with pancreatic cancer: a case-control study using linked electronic health records.BMC cancer · 2021Observational
- Global trends in pancreas cancer among Asia-Pacific population.Journal of gastrointestinal oncology · 2021Review
- Pancreatic Cancer Exposome Profile to Aid Early Detection and Inform Prevention Strategies.Journal of clinical medicine · 2021Review
- Dietary and Lifestyle Factors Associated with Gastric and Pancreatic Cancers: A Case-Control Study.Preventive nutrition and food science · 2021Article
- Epigenome-Wide Association Study Using Prediagnostic Bloods Identifies New Genomic Regions Associated With Pancreatic Cancer Risk.JNCI cancer spectrum · 2020Article
- Article
- Long-term proton pump inhibitor usage and the association with pancreatic cancer in Sweden.Journal of gastroenterology · 2020Article
- Long-term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers.Cancer medicine · 2016Article
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Authors and funding
26 authors at 20 institutions in 8 countries.
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Abstract
backgroundPeptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent.
methodsWe pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models.
resultsThe OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors.
conclusionsThis uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.
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