ArticleLab on a chip2013
Hybrid optofluidic integration.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Optofluidic chip with directly printed polymer optical waveguide Mach-Zehnder interferometer sensors for label-free biodetection.Biomedical optics express · 2024Article
- A novel hardmask-to-substrate pattern transfer method for creating 3D, multi-level, hierarchical, high aspect-ratio structures for applications in microfluidics and cooling technologies.Scientific reports · 2022Article
- All-in-One Optofluidic Chip for Molecular Biosensing Assays.Biosensors · 2022Article
- Planar Optofluidic Integration of Ring Resonator and Microfluidic Channels.Micromachines · 2022Article
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- The Rise of the OM-LoC: Opto-Microfluidic Enabled Lab-on-Chip.Micromachines · 2021Review
- Recent advances in integrated solid-state nanopore sensors.Lab on a chip · 2021Review
- Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Optofluidic detection setup for multi-parametric analysis of microbiological samples in droplets.Biomicrofluidics · 2020Article
- Multi-channel velocity multiplexing of single virus detection on an optofluidic chip.Optics letters · 2018Article
- Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.Biomedical optics express · 2018Article
- Scalable Spatial-Spectral Multiplexing of Single-Virus Detection Using Multimode Interference Waveguides.Scientific reports · 2017Article
- Optofluidic bioanalysis: fundamentals and applications.Nanophotonics (Berlin, Germany) · 2017Article
- On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood.Biomicrofluidics · 2016Article
- Flexible optofluidic waveguide platform with multi-dimensional reconfigurability.Scientific reports · 2016Article
- Single-virus analysis through chip-based optical detection.Bioanalysis · 2016Article
- Optofluidic devices with integrated solid-state nanopores.Mikrochimica acta · 2016Article
- Liquid Core ARROW Waveguides: A Promising Photonic Structure for Integrated Optofluidic Microsensors.Micromachines · 2016Review
- Spectrally reconfigurable integrated multi-spot particle trap.Optics letters · 2015Article
- Optofluidic wavelength division multiplexing for single-virus detection.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Complete integration of microfluidic and optical functions in a single lab-on-chip device is one goal of optofluidics. Here, we demonstrate the hybrid integration of a PDMS-based fluid handling layer with a silicon-based optical detection layer in a single optofluidic system. The optical layer consists of a liquid-core antiresonant reflecting optical waveguide (ARROW) chip that is capable of single particle detection and interfacing with optical fiber. Integrated devices are reconfigurable and able to sustain high pressures despite the small dimensions of the liquid-core waveguide channels. We show the combination of salient sample preparation capabilities-particle mixing, distribution, and filtering-with single particle fluorescence detection. Specifically, we demonstrate fluorescent labelling of λ-DNA, followed by flow-based single-molecule detection on a single device. This points the way towards amplification-free detection of nucleic acids with low-complexity biological sample preparation on a chip.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.