Evidence map›Paper›PMID 23969679›Full record

Trial reportBritish dental journal2013

Treatment of early caries lesions using biomimetic self-assembling peptides--a clinical safety trial.

P A Brunton, R P W Davies, J L Burke, A Smith, A Aggeli, S J Brookes, J Kirkham

3 registry-linked trialsAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British dental journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02101255 nacompletednot on this mapstarted 2014, after this paper: background citation

Effect of Curodont™ Repair in Patients With Early Approximal Carious Lesions: A Mono-centre, Controlled, Single-blinded, Randomised, Split-mouth, Post-marketing Study

TypeinterventionalSponsorCredentis AGRan2014 to 2017Enrolled25ConditionsDental CariesArmsCurodont Repair, Fluoride
NCT02119507 nacompletednot on this map

Effect of Curodont Repair in Patients With Early Approximal Carious Lesions: A Mono-centre, Controlled, Single-blinded, Randomised, Post-marketing Study

TypeinterventionalSponsorCredentis AGRan2013 to 2014Enrolled25ConditionsDental CariesArmsCurodont Repair, No treatment - control
NCT04933331 unknown statusnot on this mapstarted 2020, after this paper: background citation

An Observational Multi-cite Study to Evaluate and Compare the Effectiveness of Various Tooth Specific Treatments in the Management of Early Caries Lesions

TypeobservationalSponsorCareQuest Institute for Oral HealthRan2020 to 2024Enrolled744ConditionsInitial Caries, Arrested Dental Caries, Cavitated Caries, Dental CariesArmsCurodont Repair Fluoride Plus, Silver Diamine Fluoride, Glass Ionomer Sealant, Fluoride varnish, Fluoride toothpaste
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Self-assembling peptides for managing white spot lesions: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Efficacy of PScientific reports · 2020
    Trial
  8. Trial
  9. Effect of self-assembling peptide PScientific reports · 2020
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Self-assembling Peptide PJournal of dental research · 2018
    Trial
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

P A BruntonRestorative Dentistry, Leeds Dental Institute, University of Leeds, Clarendon Way, Leeds, LS2 9LU, UK.
R P W Davies
J L Burke
A Smith
A Aggeli
S J Brookes
J Kirkham

Funding

Wellcome TrustWellcome Trust 088,908/Z/09/Z
6 · The paper itself

Abstract

objectiveWe previously reported that a rationally designed biomimetic self-assembling peptide, P₁₁-4, nucleated hydroxyapatite de novo and was apparently capable of in situ enamel regeneration following infiltration into caries-like lesions. Our present aim was to determine the safety and potential clinical efficacy of a single application of P₁₁-4 on early enamel lesions. MATERIALS AND

methodsFifteen healthy adults with Class V 'white spot' lesions received a single application of P₁₁-4. Adverse events and lesion appearances were recorded over 180 days.

resultsPatients treated with P₁₁-4 experienced a total of 11 adverse events during the study, of which two were possibly related to the protocol. Efficacy evaluation suggested that treatment with P₁₁-4 significantly decreased lesion size (p = 0.02) after 30 days and shifted the apparent progression of the lesions from 'arrested/progressing' to 'remineralising' (p <0.001). A highly significant improvement in the global impression of change was recorded at day 30 compared with baseline (p <0.001).

conclusionsThe results suggest that treatment of early caries lesions with P₁₁-4 is safe, and that a single application is associated with significant enamel regeneration, presumably by promoting mineral deposition within the subsurface tissue.

Indexed as

AdolescentAdultAgedBiomimetic MaterialsDental CariesDental EnamelDentin SensitivityDisease ProgressionDurapatiteFemaleFollow-Up StudiesHumansMaleMiddle AgedOligopeptidesPeptidesDurapatiteOligopeptidesP11-4 peptidePeptides

Identifiers

PMID23969679
PMCPMC3813405

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.