ArticleNature2013
Medical research: Trial unpredictability yields predictable therapy gains.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Accuracy of Event Rate and Effect Size Estimation in Major Cardiovascular Trials: A Systematic Review.JAMA network open · 2024Pooled it
- US Food and Drug Administration Approvals of Drugs and Devices Based on Nonrandomized Clinical Trials: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Is the decision on the use of biosimilar growth hormone based on high quality scientific evidence? - a systematic review.European journal of clinical pharmacology · 2014Pooled it
- Trial
- The statistical properties of RCTs and a proposal for shrinkage.Statistics in medicine · 2021Trial
- Article
- The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial.Brain & spine · 2024Article
- Large numbers of patients are needed to obtain additional approvals for new cancer drugs: A retrospective cohort study.Scientific reports · 2023Article
- Identification of threshold for large (dramatic) effects that would obviate randomized trials is not possible.Journal of clinical epidemiology · 2022Article
- Review
- Unperceived similarities between clinical trials and quantum physics.British journal of clinical pharmacology · 2020Article
- Design analysis indicates Potential overestimation of treatment effects in randomized controlled trials supporting Food and Drug Administration cancer drug approvals.Journal of clinical epidemiology · 2018Article
- 'Optimism bias' in contemporary national clinical trial network phase III trials: are we improving?Annals of oncology : official journal of the European Society for Medical Oncology · 2018Article
- Most medical practices are not parachutes: a citation analysis of practices felt by biomedical authors to be analogous to parachutes.CMAJ open · 2018Article
- Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy?Journal of general internal medicine · 2018Article
- Article
- Randomly auditing research labs could be an affordable way to improve research quality: A simulation study.PloS one · 2018Article
- Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.Clinical trials (London, England) · 2017Article
- Overcoming obstacles in the design of cancer anorexia/weight loss trials.Critical reviews in oncology/hematology · 2017Review
- Efficient design of clinical trials and epidemiological research: is it possible?Nature reviews. Cardiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.