ArticleCortex; a journal devoted to the study of the nervous system and behavior2014
Neural correlates of the relationship between discourse coherence and sensory monitoring in schizophrenia.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Aberrant brain language network in schizophrenia spectrum disorder: a systematic review of its relation to language signs beyond symptoms.Frontiers in psychiatry · 2024Pooled it
- Neural correlates of formal thought disorder: An activation likelihood estimation meta-analysis.Human brain mapping · 2017Pooled it
- Lowering costs for large-scale screening in psychosis: a systematic review and meta-analysis of performance and value of information for speech-based psychiatric evaluation.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- A window into the intoxicated mind? Speech as an index of psychoactive drug effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach.Molecular psychiatry · 2026Article
- Expressive pragmatic language in mood and psychotic disorders: a systematic review and meta-analysis.Schizophrenia (Heidelberg, Germany) · 2026Review
- Reduced linguistic coherence in psychosis defies semantic similarity accounts and relates to altered large-scale cortical hierarchy.Scientific reports · 2026Article
- Automated analysis of speech as a marker of sub-clinical psychotic experiences.Frontiers in psychiatry · 2023Review
- Progressive changes in descriptive discourse in First Episode Schizophrenia: a longitudinal computational semantics study.Schizophrenia (Heidelberg, Germany) · 2022Article
- Language as a biomarker for psychosis: A natural language processing approach.Schizophrenia research · 2020Review
- The role of microstructural integrity of major language pathways in narrative speech in the first year after stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Linking language features to clinical symptoms and multimodal imaging in individuals at clinical high risk for psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Using Language Processing and Speech Analysis for the Identification of Psychosis and Other Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
- A machine learning approach to predicting psychosis using semantic density and latent content analysis.NPJ schizophrenia · 2019Article
- Reductions in prefrontal activation predict off-topic utterances during speech production.Nature communications · 2019Article
- Aberrant Temporal Connectivity in Persons at Clinical High Risk for Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Can RDoC Help Find Order in Thought Disorder?Schizophrenia bulletin · 2017Review
- An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Automated computerized analysis of speech in psychiatric disorders.Current opinion in psychiatry · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Unusual language use is a core feature of psychosis, but the nature and significance of this are not understood. In particular, thought disorder in schizophrenia (SZ) is characterized by markedly bizarre speech, but the cognitive components that contribute to this and the brain correlates of these components are unknown. A number of studies have demonstrated language abnormalities in single word processing, but few have examined speech in SZ at the discourse level. This has been at least partly due to the difficulty in quantifying content of discourse. Recently, methods in computational linguistics have been found to be useful for detecting differences in semantic coherence during discourse between different clinical groups. We build on this work by demonstrating how these methods can be combined with funtional magnetic resonance imaging (fMRI) in order to tease apart factors that underlie free discourse and its deviations, and how they relate to brain activity. Eleven volunteers with SZ and eleven controls participated in an interview during which they were asked to talk as much as they could about 'religious belief'. These same participants underwent fMRI during a word monitoring task, during which modality of monitoring was manipulated by varying the congruence of auditory and visual stimuli. Semantic coherence scores, measured from free discourse, were examined for their relationship to brain activations during fMRI. In healthy controls, regions associated with executive function were related to coherence. In persons with SZ, coherence was mainly related to auditory and visual regions, depending on the modality of monitoring, but superior/middle temporal cortex related to coherence regardless of task. These findings are consistent with existing evidence for a role of superior temporal cortex in thought disorder, and demonstrate that computational measures of semantic content capture objective measures of coherence in speech that can be usefully related to underlying neurophysiological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.