ArticleEnvironmental health perspectives2013
Early life arsenic exposure and acute and long-term responses to influenza A infection in mice.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Pooled it
- Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages.Toxicology · 2025Article
- Association between heavy metals exposure and persistent infections: the mediating role of immune function.Frontiers in public health · 2024Article
- Long-term effects of prenatal arsenic exposure from gestational day 9 to birth on lung, heart, and immune outcomes in the C57BL/6 mouse model.Toxicology letters · 2023Article
- Article
- Down-regulation of RdRp complex and activated immune response due to increased arsenic level leads to decreased corona virus replication.Current research in microbial sciences · 2022Article
- Paradoxical effects of arsenic in the lungs.Environmental health and preventive medicine · 2021Review
- Single-cell RNA-seq Analysis Reveals That Prenatal Arsenic Exposure Results in Long-term, Adverse Effects on Immune Gene Expression in Response to Influenza A Infection.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Chronic exposure to arsenite enhances influenza virus infection in cultured cells.Journal of applied toxicology : JAT · 2020Article
- Dose and Diet - Sources of Arsenic Intake in Mouse in Utero Exposure Scenarios.Chemical research in toxicology · 2018Article
- Unique pulmonary immunotoxicological effects of urban PM are not recapitulated solely by carbon black, diesel exhaust or coal fly ash.Environmental research · 2018Article
- Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice.Environmental health perspectives · 2017Article
- Arsenic exposure impels CD4 commitment in thymus and suppress T cell cytokine secretion by increasing regulatory T cells.Scientific reports · 2017Article
- Arsenic and Immune Response to Infection During Pregnancy and Early Life.Current environmental health reports · 2017Review
- Burn Injury Leads to Increased Long-Term Susceptibility to Respiratory Infection in both Mouse Models and Population Studies.PloS one · 2017Article
- Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort.Environmental health perspectives · 2016Article
- A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment.Environmental science and pollution research international · 2016Review
- Arsenic exposure and prevalence of the varicella zoster virus in the United States: NHANES (2003-2004 and 2009-2010).Environmental health perspectives · 2015Article
- Healthy vinton: a health impact assessment focused on water and sanitation in a small rural town on the US-Mexico border.International journal of environmental research and public health · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood.
objectiveWe aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice.
methodsC57BL/6 mice were exposed to arsenic in utero and throughout postnatal life. At 1 week of age, a subgroup of mice were infected with influenza A. We then assessed the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function.
resultsEarly life arsenic exposure reduced the clearance of and exacerbated the inflammatory response to influenza A, and resulted in acute and long-term changes in lung mechanics and airway structure.
conclusionsIncreased susceptibility to respiratory infections combined with exaggerated inflammatory responses throughout early life may contribute to the development of bronchiectasis in arsenic-exposed populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.