ArticleThe Journal of the Acoustical Society of America2013
Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study.
Article in The Journal of the Acoustical Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors.PLoS computational biology · 2025Article
- NIR-Responsive Microbubble Delivery Platforms for Controlled Drug Release in Cancer Therapy.Materials (Basel, Switzerland) · 2025Article
- Synergistic mechanotherapy and sonopermeation guided by mathematical modeling for solid tumor treatment.Frontiers in drug delivery · 2025Article
- Innovative Approaches to Brain Cancer: The Use of Magnetic Resonance-guided Focused Ultrasound in Glioma Therapy.Cancers · 2024Review
- Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier.Nature communications · 2024Article
- Weakly nonlinear focused ultrasound in viscoelastic media containing multiple bubbles.Ultrasonics sonochemistry · 2023Article
- A review on photo-mediated ultrasound therapy.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Feasibility of photoacoustic-guided ultrasound treatment for port wine stains.Lasers in surgery and medicine · 2023Article
- Weakly nonlinear propagation of focused ultrasound in bubbly liquids with a thermal effect: Derivation of two cases of Khokolov-Zabolotskaya-Kuznetsoz equations.Ultrasonics sonochemistry · 2022Article
- Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes - a pre-clinical study.The British journal of radiology · 2022Article
- A 3D finite element model to study the cavitation induced stresses on blood-vessel wall during the ultrasound-only phase of photo-mediated ultrasound therapy.AIP advances · 2022Article
- Vascular Imaging in Small Animals Using Clinical Ultrasound Scanners.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study.Journal of biomedical physics & engineering · 2021Article
- Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain.Scientific reports · 2020Article
- Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening.Frontiers in physics · 2020Article
- Longitudinal Motor and Behavioral Assessment of Blood-Brain Barrier Opening with Transcranial Focused Ultrasound.Ultrasound in medicine & biology · 2016Article
- A Two-Criterion Model for Microvascular Bio-Effects Induced In Vivo by Contrast Microbubbles Exposed to Medical Ultrasound.Ultrasound in medicine & biology · 2016Article
- In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications.Biomicrofluidics · 2016Review
- Microbubbles and blood-brain barrier opening: a numerical study on acoustic emissions and wall stress predictions.IEEE transactions on bio-medical engineering · 2015Article
- Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Oscillating microbubbles within microvessels could induce stresses that lead to bioeffects or vascular damage. Previous work has attributed vascular damage to the vessel expansion or bubble jet. However, ultra-high speed images of recent studies suggest that it could happen due to the vascular invagination. Numerical simulations of confined bubbles could provide insight into understanding the mechanism behind bubble-vessel interactions. In this study, a finite element model of a coupled bubble/fluid/vessel system was developed and validated with experimental data. Also, for a more realistic study viscoelastic properties of microvessels were assessed and incorporated into this comprehensive numerical model. The wall shear stress (WSS) and circumferential stress (CS), metrics of vascular damage, were calculated from these simulations. Resultant amplitudes of oscillation were within 15% of those measured in experiments (four cases). Among the experimental cases, it was numerically found that maximum WSS values were between 1.1-18.3 kPa during bubble expansion and 1.5-74 kPa during bubble collapse. CS was between 0.43-2.2 MPa during expansion and 0.44-6 MPa while invaginated. This finding confirmed that vascular damage could occur during vascular invaginations. Predicted thresholds in which these stresses are higher during vessel invagination were calculated from simulations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.