ArticleCell division2013
Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase.
Article in Cell division, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- A comparative study on recombination activity in cattle.Genetics, selection, evolution : GSE · 2026Article
- Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells.Advances in experimental medicine and biology · 2026Review
- Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase.Current biology : CB · 2024Article
- The kleisin subunit controls the function ofeLife · 2023Article
- Identification of sex determination locus in sea cucumber Apostichopus japonicus using genome-wide association study.BMC genomics · 2022Article
- Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space.Essays in biochemistry · 2020Review
- Is age-related increase of chromosome segregation errors in mammalian oocytes caused by cohesin deterioration?Reproductive medicine and biology · 2020Review
- SOX2 participates in spermatogenesis of Zhikong scallop Chlamys farreri.Scientific reports · 2019Article
- The cohesin complex in mammalian meiosis.Genes to cells : devoted to molecular & cellular mechanisms · 2019Review
- Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation.Current biology : CB · 2016Article
- BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo.Stem cell reports · 2016Article
- Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice.Current biology : CB · 2016Article
- Complex elaboration: making sense of meiotic cohesin dynamics.The FEBS journal · 2015Review
- Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation.PLoS genetics · 2014Article
- Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.Chromosoma · 2014Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundSister chromatid cohesion mediated by the cohesin complex is essential for accurate chromosome segregation during mitosis and meiosis. Loading of cohesin onto chromosomes is dependent on another protein complex called kollerin, containing Nipbl/Scc2 and Mau2/Scc4. Nipbl is an evolutionarily conserved large protein whose haploinsufficiency in humans causes a developmental disorder called Cornelia de Lange syndrome. Although the function of Nipbl homologues for chromosome cohesion in meiotic cells of non-vertebrate models has been elucidated, Nipbl has not been characterized so far in mammalian spermatocytes or oocytes.
findingsHere we describe our analyses on the expression and localization of Nipbl in nuclei of mouse spermatocytes and oocytes at different stages of meiotic prophase. In both spermatocytes and oocytes we found that Nipbl is associated with the axial/lateral element of the synaptonemal complex (AE/LE) to which cohesin also localizes. Interestingly, Nipbl in spermatocytes, but not in oocytes, dissociates from the AE/LE at mid-pachytene stage coincident with completion of DNA double-strand break repair.
conclusionsOur data propose that cohesin loading activity is maintained during early stages of meiotic prophase in mammalian spermatocytes and oocytes.
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